Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | CRACR2A | Q9BSW2 | 6/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | CHRNE | Q04844 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6622049 | 0.93 | RAB9A (0.39) | CRACR2AKCNJ6KCNJ5KCNJ3JAK2 | |
| SCHEMBL6617364 | 0.92 | CNR1 (0.42) | EPHX2DPP4CRACR2ACNR1KCNJ6 | |
| SCHEMBL6634119 | 0.92 | CNR1 (0.42) | EPHX2DPP4CRACR2ACNR1KCNJ6 | |
| SCHEMBL6620593 | 0.91 | HRH3 (0.39) | EPHX2CRACR2ACNR1JAK2JAK1 | |
| SCHEMBL6614980 | 0.88 | CNR1 (0.42) | EPHX2DPP4CNR1KCNJ6KCNJ5 | |
| SCHEMBL6622320 | 0.88 | MAPT (0.42) | — | |
| SCHEMBL6617644 | 0.87 | ACKR3 (0.40) | CRACR2ACNR1KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL6616846 | 0.86 | NAMPT (0.42) | NAMPTJAK2CHRNEPTGDR2 | |
| SCHEMBL6618429 | 0.86 | ACKR3 (0.44) | CNR1TYK2 | |
| SCHEMBL6616321 | 0.86 | CHRNE (0.38) | EPHX2KCNJ6KCNJ5KCNJ3NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |