Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 3/20 | 0.47 |
| ▸ | SLC22A2 | O15244 | 2/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.47 |
| ▸ | SLC22A3 | O75751 | 2/20 | 0.47 |
| ▸ | NOS1 | P29475 | 2/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.43 |
| ▸ | HTR3B | O95264 | 2/20 | 0.43 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4215248 | 0.90 | HTR3E (0.53) | PLAUSLC22A2SLC22A1SLC22A3NOS1 | |
| SCHEMBL1753035 | 0.82 | FLT1 (0.44) | PLAUSLC22A2SLC22A1SLC22A3NOS1 | |
| SCHEMBL2115124 | 0.82 | FLT1 (0.44) | PLAUSLC22A2SLC22A1SLC22A3NOS1 | |
| SCHEMBL4516878 | 0.80 | HTR3E (0.51) | PLAUSLC22A2SLC22A1SLC22A3NOS1 | |
| SCHEMBL4517019 | 0.80 | RAB9A (0.55) | NOS1FLT1FLT4KDRHTR3E | |
| SCHEMBL101867 | 0.73 | USP2 (0.65) | RAB9ANPC1HPGDCASP3SENP7 | |
| SCHEMBL29478736 | 0.73 | USP2 (0.65) | RAB9ANPC1HPGDCASP3SENP7 | |
| SCHEMBL101868 | 0.73 | USP2 (0.65) | RAB9ANPC1HPGDCASP3SENP7 | |
| SCHEMBL11771956 | 0.71 | CYP2D6 (0.56) | PLAUSLC22A2SLC22A1SLC22A3NOS1 | |
| SCHEMBL7868755 | 0.69 | KMT2A (0.50) | FLT1FLT4KDRRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234928-A1 | Novel Compounds for Treating Fibrosis and Inflammatory Conditions | MAKSCIENTIFIC, LLC | 2023-07-27 | — | — | US | disclosed |
| WO-2022026478-A1 | NOVEL COMPOUNDS FOR TREATING FIBROSIS AND INFLAMMATORY CONDITIONS | MAKSCIENTIFIC, LLC (US) | 2022-02-03 | — | — | WO | disclosed |
| US-8853205-B2 | Heteropyrrole analogs acting on cannabinoid receptors | UNIVERSITY OF CONNECTICUT (US) | 2014-10-07 | — | — | US | disclosed |
| US-8729101-B2 | 1H-imidazole derivative having CB1, agonistic, CB1 partial agonistic or CB1 antagnistic activity | SOLVAY PHARMACEUTICALS, B.V. (NL) | 2014-05-20 | — | — | US | disclosed |
| US-20120046280-A1 | NOVEL HETEROPYRROLE ANALOGS ACTING ON CANNABINOID RECEPTORS | UNIVERSITY OF CONNECTICUT | 2012-02-23 | — | — | US | disclosed |
| EP-2398323-A1 | NOVEL HETERO PYRROLE ANALOGS ACTING ON CANNAPINOID RECEPTORS | University of Connecticut (US) | 2011-12-28 | — | — | EP | disclosed |
| US-8084451-B2 | Heteropyrrole analogs acting on cannabinoid receptors | UNIVERSITY OF CONNECTICUT (US) | 2011-12-27 | — | — | US | disclosed |
| EP-2368881-A1 | Heteropyrazole analogs acting on cannabinoid receptors | University of Connecticut (US) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010104488-A1 | NOVEL HETERO PYRROLE ANALOGS ACTING ON CANNAPINOID RECEPTORS | UNIVERSITY OF CONNECTICUT (US) | 2010-09-16 | — | — | WO | disclosed |
| US-20100063050-A1 | NOVEL HETEROPYRROLE ANALOGS ACTING ON CANNABINOID RECEPTORS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2010-03-11 | — | — | US | disclosed |
| US-20090181949-A1 | 1H-IMIDAZOLE DERIVATIVE HAVING CB1, AGONISTIC, CB1 PARTIAL AGONISTIC OR CB1 ANTAGNISTIC ACTIVITY | SOLVAY PHARMACEUTICALS B.V. | 2009-07-16 | — | — | US | disclosed |
| EP-1438296-B1 | 1H-IMIDAZOLE DERIVATIVES HAVING CB1 AGONISTIC, CB1 PARTIAL AGONISTIC OR CB1- ANTAGONISTIC ACTIVITY | SOLVAY PHARM BV (NL) | 2008-11-26 | — | — | EP | disclosed |
| EP-1845972-A2 | NOVEL HETEROPYRROLE ANALOGS ACTING ON CANNABINIOD RECEPTORS | University of Connecticut (US) | 2007-10-24 | — | — | EP | disclosed |
| US-7109216-B2 | 1H-imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity | SOLVAY PHARMACEUTICALS B.V. (NL) | 2006-09-19 | — | — | US | disclosed |
| WO-2006074445-A2 | NOVEL HETEROPYRROLE ANALOGS ACTING ON CANNABINIOD RECEPTORS | MAKRIYANNIS ALEXANDROS (US) | 2006-07-13 | — | — | WO | disclosed |
| US-20050054679-A1 | 1 H-imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity | SOLVAY PHARMACEUTICALS B.V. | 2005-03-10 | — | — | US | disclosed |
| CN-1556703-A | With CB1Agonistic activity, CB1Partial agonist Activity or CB11H-imidazole derivatives with antagonistic activity | ������ҩ������˾ | 2004-12-22 | — | — | CN | disclosed |
| US-20040235854-A1 | 1H-imidazole derivatives having cb1 agonistic, cb1 partial agonistic or cb1 antagonistic activity | SOLVAY PHARMACEUTICALS B.V. (NL) | 2004-11-25 | — | — | US | disclosed |
| EP-1438296-A2 | 1H-IMIDAZOLE DERIVATIVES HAVING CB1 AGONISTIC, CB1 PARTIAL AGONISTIC OR CB1- ANTAGONISTIC ACTIVITY | Solvay Pharmaceuticals B.V. (NL) | 2004-07-21 | — | — | EP | disclosed |
| WO-2003027076-A2 | 1H-IMIDAZOLE DERIVATIVES HAVING CB1 AGONISTIC, CB1 PARTIAL AGONISTIC OR CB1- ANTAGONISTIC ACTIVITY | SOLVAY PHARMACEUTICALS B.V. (NL) | 2003-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181949-A1 | 1H-IMIDAZOLE DERIVATIVE HAVING CB1, AGONISTIC, CB1 PARTIAL AGONISTIC OR CB1 ANTAGNISTIC ACTIVITY | CNR1, CNR2, CHRM1 | PLAU 4676/4885SLC22A2 3718/4885SLC22A1 3335/4885 |
| US-20120046280-A1 | NOVEL HETEROPYRROLE ANALOGS ACTING ON CANNABINOID RECEPTORS | CNR1, CNR2, CBR3 | PLAU 4331/4885SLC22A2 4668/4885SLC22A1 4666/4885 |
| US-20100063050-A1 | NOVEL HETEROPYRROLE ANALOGS ACTING ON CANNABINOID RECEPTORS | CNR2, CNR1, GPR18 | PLAU 4383/4885SLC22A2 4594/4885SLC22A1 4668/4885 |
| US-20040235854-A1 | 1H-imidazole derivatives having cb1 agonistic, cb1 partial agonistic or cb1 antagonistic activity | CNR1, CNR2, CHRM1 | PLAU 4228/4885SLC22A2 4518/4885SLC22A1 4252/4885 |
| US-20050054679-A1 | 1 H-imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity | CNR1, CNR2, HRH4 | PLAU 4260/4885SLC22A2 4374/4885SLC22A1 4188/4885 |
| US-20230234928-A1 | Novel Compounds for Treating Fibrosis and Inflammatory Conditions | CNR2, CNR1, GPR174 | PLAU 2954/4885SLC22A2 4450/4885SLC22A1 4393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.