Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 9/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.59 |
| ▸ | ADRB3 | P13945 | 9/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960624 | 0.83 | L3MBTL1 (0.57) | MAPK1TSHRKDM4EPOLB | |
| SCHEMBL6621718 | 0.82 | MAPK1 (0.47) | MAPK1KDM4EPOLB | |
| SCHEMBL6619778 | 0.81 | KMT2A (0.57) | MAPK1TSHRKDM4EPOLB | |
| SCHEMBL6997223 | 0.81 | ADRB2 (0.51) | ADRB2ADRB1ADRB3KCNH2MAPK1 | |
| SCHEMBL6622630 | 0.80 | MEN1 (0.53) | KCNH2MAPK1HSD17B10KDM4EPOLB | |
| SCHEMBL6619543 | 0.80 | MEN1 (0.53) | KCNH2MAPK1HSD17B10KDM4EPOLB | |
| SCHEMBL6995821 | 0.79 | KCNH2 (0.53) | ADRB2ADRB1ADRB3KCNH2PRMT5 | |
| SCHEMBL6624652 | 0.78 | DRD4 (0.56) | MAPK1KDM4EPOLB | |
| SCHEMBL9470868 | 0.75 | ADRB2 (0.65) | ADRB2ADRB1ADRB3KCNH2KDM4E | |
| SCHEMBL6622527 | 0.75 | SMN1; SMN2 (0.41) | KCNH2PRMT5WDR77MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047695-B1 | NOVEL BISPIDINE ANTIARRHYTHMIC COMPOUNDS | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | disclosed |
| US-6291475-B1 | 3,7-DIAZABICYCLO(3.3.1)NONANE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-09-18 | — | — | US | disclosed |