Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 7/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.65 |
| ▸ | ADRB3 | P13945 | 7/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SCN1A | P35498 | 1/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9471731 | 0.83 | LTA4H (0.63) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9444448 | 0.82 | KCNH2 (0.56) | ADRB2ADRB1ADRB3KCNH2SMN1; SMN2 | |
| SCHEMBL10580036 | 0.82 | KCNH2 (0.56) | ADRB2ADRB1ADRB3KCNH2SMN1; SMN2 | |
| SCHEMBL9444381 | 0.79 | KCNH2 (0.56) | ADRB2ADRB1ADRB3KCNH2SMN1; SMN2 | |
| SCHEMBL12722227 | 0.79 | CYP2D6 (0.69) | ADRB2ADRB1ADRB3SMN1; SMN2MAPT | |
| SCHEMBL9444349 | 0.79 | KCNH2 (0.62) | KCNH2SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL9839933 | 0.79 | ADRB2 (1.00) | ADRB2ADRB1ADRB3KCNH2MAPT | |
| SCHEMBL9480753 | 0.79 | LTA4H (0.57) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| Hydrochloric Acid SCHEMBL9444401 | 0.78 | KCNH2 (0.62) | KCNH2SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL12722228 | 0.77 | CACNA1G (0.64) | ADRB2ADRB1ADRB3KCNH2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202346-A | Antiarrhythmic agent | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-04-13 | — | — | US | claimed |
| US-5254689-A | Antiarrhythmia agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-19 | — | — | US | disclosed |