Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6621097 | 0.86 | ALDH1A1 (0.50) | DRD4TDP1ALDH1A1MAPTHTT | |
| SCHEMBL6737742 | 0.86 | ALDH1A1 (0.50) | DRD4TDP1ALDH1A1MAPTHTT | |
| SCHEMBL7960624 | 0.85 | L3MBTL1 (0.57) | DRD4MAPTHTTLMNAKMT2A | |
| SCHEMBL6621718 | 0.84 | MAPK1 (0.47) | DRD4MAPTKMT2AMEN1MAPK1 | |
| SCHEMBL6622630 | 0.83 | MEN1 (0.53) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6619543 | 0.83 | MEN1 (0.53) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6619778 | 0.82 | KMT2A (0.57) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6619294 | 0.81 | DRD4 (0.46) | DRD4TDP1ALDH1A1MAPTHTT | |
| SCHEMBL6620166 | 0.78 | ADRB2 (0.59) | MAPK1KDM4EPOLB | |
| SCHEMBL6622872 | 0.78 | L3MBTL1 (0.45) | DRD4TDP1ALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047695-B1 | NOVEL BISPIDINE ANTIARRHYTHMIC COMPOUNDS | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | disclosed |
| US-6291475-B1 | 3,7-DIAZABICYCLO(3.3.1)NONANE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-09-18 | — | — | US | disclosed |