Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | CTSG | P08311 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | CTRC | Q99895 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6620106 | 0.79 | ELANE (0.53) | KMT2AALDH1A1MEN1TSHRSMN1; SMN2 | |
| SCHEMBL4187348 | 0.75 | CYP3A4 (0.53) | KMT2AALDH1A1MEN1TSHRHIF1A | |
| SCHEMBL6623233 | 0.74 | ALDH1A1 (0.51) | KMT2AALDH1A1MEN1TSHRSMN1; SMN2 | |
| SCHEMBL6621853 | 0.74 | ALDH1A1 (0.55) | KMT2AALDH1A1MEN1TSHRSMN1; SMN2 | |
| SCHEMBL10068628 | 0.74 | ALDH1A1 (0.54) | KMT2AALDH1A1MEN1TSHRSMN1; SMN2 | |
| SCHEMBL6549403 | 0.70 | KMT2A (0.77) | KMT2AALDH1A1MEN1SMN1; SMN2LMNA | |
| SCHEMBL21306170 | 0.70 | MAPT (0.31) | ALDH1A1MAPK1 | |
| SCHEMBL16775234 | 0.69 | KMT2A (0.70) | KMT2AALDH1A1MEN1TSHRSMN1; SMN2 | |
| SCHEMBL16759895 | 0.69 | KMT2A (0.70) | KMT2AALDH1A1MEN1TSHRSMN1; SMN2 | |
| SCHEMBL5770320 | 0.68 | ALDH1A1 (0.69) | KMT2AALDH1A1MEN1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047695-B1 | NOVEL BISPIDINE ANTIARRHYTHMIC COMPOUNDS | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | disclosed |
| US-6291475-B1 | 3,7-DIAZABICYCLO(3.3.1)NONANE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-09-18 | — | — | US | disclosed |