Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 15/20 | 0.62 |
| ▸ | MMP13 | P45452 | 15/20 | 0.62 |
| ▸ | MMP2 | P08253 | 14/20 | 0.62 |
| ▸ | MMP3 | P08254 | 14/20 | 0.62 |
| ▸ | MMP14 | P50281 | 13/20 | 0.62 |
| ▸ | MMP8 | P22894 | 13/20 | 0.62 |
| ▸ | MMP1 | P03956 | 9/20 | 0.58 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | MMP10 | P09238 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7429722 | 0.85 | MMP9 (0.72) | MMP9MMP13MMP2MMP3MMP14 | |
| SCHEMBL5919515 | 0.78 | MMP3 (1.00) | MMP9MMP13MMP2MMP3MMP14 | |
| SCHEMBL6621747 | 0.76 | MMP9 (0.63) | MMP9MMP13MMP2MMP3MMP14 | |
| SCHEMBL5919254 | 0.75 | MMP9 (1.00) | MMP9MMP13MMP2MMP3MMP14 | |
| SCHEMBL6464999 | 0.74 | MMP13 (1.00) | MMP9MMP13MMP2MMP3MMP14 | |
| SCHEMBL7422009 | 0.74 | MMP3 (0.69) | MMP9MMP13MMP2MMP3MMP14 | |
| Hydrochloric Acid SCHEMBL6691933 | 0.73 | MMP3 (0.68) | MMP9MMP13MMP2MMP3MMP14 | |
| Hydrochloric Acid SCHEMBL6694879 | 0.73 | MMP3 (0.68) | MMP9MMP13MMP2MMP3MMP14 | |
| Sulfuric Acid SCHEMBL7435751 | 0.72 | MMP3 (0.67) | MMP9MMP13MMP2MMP3MMP14 | |
| SCHEMBL6685408 | 0.72 | MMP13 (0.66) | MMP9MMP13MMP2MMP3MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472244-A1 | AROMATIC SULFONE HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS | Pharmacia Corporation (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003045944-A1 | AROMATIC SULFONE HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS | PHARMACIA CORPORATION (US) | 2003-06-05 | — | — | WO | disclosed |