Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8344546 | 0.86 | SIGMAR1 (0.53) | HTR1AHTR7HTR2CDRD2DRD3 | |
| SCHEMBL1038535 | 0.79 | — | — | |
| SCHEMBL8343954 | 0.78 | SIGMAR1 (0.58) | HTR1AHTR7HTR2CDRD2DRD3 | |
| SCHEMBL9175625 | 0.77 | HTR2C (0.44) | HTR2C | |
| SCHEMBL1038532 | 0.77 | HTR2C (0.44) | HTR2C | |
| SCHEMBL8346145 | 0.77 | HTR1A (0.43) | HTR1AHTR7 | |
| SCHEMBL7405539 | 0.76 | ALDH1A1 (0.53) | HTR1ADRD2DRD3 | |
| SCHEMBL5655849 | 0.75 | DRD3 (0.57) | DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL8185523 | 0.75 | ALDH1A1 (0.52) | HTR1ADRD2DRD3 | |
| SCHEMBL7401374 | 0.73 | DRD2 (0.48) | HTR1AHTR7DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0976732-B1 | 1,4-SUBSTITUTED CYCLIC AMINE DERIVATIVES | EISAI CO LTD (JP) | 2004-11-24 | — | — | EP | disclosed |
| US-5929078-A | ANTISEROTONINE AGENT | SYNTHELABO (FR) | 1999-07-27 | — | — | US | disclosed |
| US-5929078-A | ANTISEROTONINE AGENT | SYNTHELABO (FR) | 1999-07-27 | — | — | US | disclosed |
| CN-1199398-A | 1-[2-(2,3-dihydro-1H-inden-1-yl) ethyl]-4-(naphthalen-1-yl) piperazine derivs, preparation thereof and therapeutical use thereof | SYNTHELABO (FR) | 1998-11-18 | — | — | CN | disclosed |
| EP-0843670-A1 | 1-[2-(2,3-DIHYDRO-1H-INDEN-1-YL)ETHYL]-4-(NAPHTHALEN-1-YL)PIPERAZINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL USE THEREOF | SYNTHELABO (FR) | 1998-05-27 | — | — | EP | disclosed |
| WO-1997006155-A1 | 1-[2-(2,3-DIHYDRO-1H-INDEN-1-YL)ETHYL]-4-(NAPHTHALEN-1-YL)PIPERAZINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL USE THEREOF | SYNTHELABO (FR) | 1997-02-20 | — | — | WO | disclosed |