Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 4/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | EBP | Q15125 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5183866 | 0.93 | SIGMAR1 (0.54) | ADRA1AADRA1DADRA1BSIGMAR1TMEM97 | |
| SCHEMBL6623960 | 0.93 | ADRA1D (0.54) | ADRA1AADRA1DADRA1BSIGMAR1TMEM97 | |
| SCHEMBL5182997 | 0.88 | ADRA1D (0.61) | ADRA1AADRA1DADRA1BSIGMAR1TMEM97 | |
| SCHEMBL5183532 | 0.87 | ADRA1D (0.44) | ADRA1AADRA1DADRA1BSIGMAR1TMEM97 | |
| SCHEMBL5183582 | 0.84 | SIGMAR1 (0.54) | ADRA1AADRA1DADRA1BSIGMAR1TMEM97 | |
| SCHEMBL5183557 | 0.83 | SIGMAR1 (0.56) | ADRA1AADRA1DADRA1BSIGMAR1TMEM97 | |
| SCHEMBL2767412 | 0.83 | MAPT (0.63) | ADRA1AADRA1DADRA1BSIGMAR1TMEM97 | |
| SCHEMBL5183909 | 0.83 | LMNA (0.51) | ADRA1ASIGMAR1DRD2HTR1AHTR2A | |
| SCHEMBL5182166 | 0.81 | SIGMAR1 (0.53) | ADRA1AADRA1DADRA1BSIGMAR1TMEM97 | |
| SCHEMBL5183284 | 0.81 | SIGMAR1 (0.47) | ADRA1AADRA1DADRA1BSIGMAR1TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1389189-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES | NEUROGEN CORPORATION (US) | 2004-02-18 | — | — | EP | claimed |
| WO-2002094799-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES | NEUROGEN CORPORATION (US) | 2002-11-28 | — | — | WO | claimed |
| EP-1389189-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES | NEUROGEN CORPORATION (US) | 2004-02-18 | — | — | EP | disclosed |
| WO-2002094799-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES | NEUROGEN CORPORATION (US) | 2002-11-28 | — | — | WO | disclosed |