Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 4/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.51 |
| ▸ | EBP | Q15125 | 2/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | EBPL | Q9BY08 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5182997 | 0.95 | ADRA1D (0.61) | ADRA1DADRA1AADRA1BSIGMAR1EBP | |
| SCHEMBL6622293 | 0.93 | ADRA1A (0.48) | ADRA1DADRA1AADRA1BSIGMAR1EBP | |
| SCHEMBL2767412 | 0.90 | MAPT (0.63) | ADRA1DADRA1AADRA1BSIGMAR1EBP | |
| SCHEMBL5183866 | 0.85 | SIGMAR1 (0.54) | ADRA1DADRA1AADRA1BSIGMAR1EBP | |
| SCHEMBL5183532 | 0.84 | ADRA1D (0.44) | ADRA1DADRA1AADRA1BSIGMAR1EBP | |
| SCHEMBL6625036 | 0.83 | LMNA (0.55) | ADRA1ASIGMAR1SMN1; SMN2HTR1AMAPT | |
| SCHEMBL5183582 | 0.80 | SIGMAR1 (0.54) | ADRA1DADRA1AADRA1BSIGMAR1EBP | |
| SCHEMBL5182203 | 0.80 | SIGMAR1 (0.61) | ADRA1DADRA1AADRA1BSIGMAR1EBP | |
| SCHEMBL5184289 | 0.80 | LMNA (0.42) | ADRA1DADRA1AADRA1BSIGMAR1EBP | |
| SCHEMBL5183557 | 0.80 | SIGMAR1 (0.56) | ADRA1DADRA1AADRA1BSIGMAR1EBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1389189-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES | NEUROGEN CORPORATION (US) | 2004-02-18 | — | — | EP | claimed |
| WO-2002094799-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES | NEUROGEN CORPORATION (US) | 2002-11-28 | — | — | WO | claimed |
| EP-1389189-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES | NEUROGEN CORPORATION (US) | 2004-02-18 | — | — | EP | disclosed |
| WO-2002094799-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES | NEUROGEN CORPORATION (US) | 2002-11-28 | — | — | WO | disclosed |