Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 7/20 | 0.39 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.37 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.36 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | F2R | P25116 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6622840 | 0.92 | PTGES (0.42) | HRH3DRD2ADRA1APTGESTAOK1 | |
| SCHEMBL6616965 | 0.90 | HRH3 (0.40) | HRH3PTGESTAOK1TAOK3EPHX2 | |
| SCHEMBL6616492 | 0.89 | HRH3 (0.38) | HRH3PTGESTAOK1TAOK3EPHX2 | |
| SCHEMBL6616711 | 0.88 | NPC1 (0.40) | DRD2ADRA1AERCC1ERCC4RECQL | |
| SCHEMBL6614045 | 0.88 | EPHX2 (0.41) | HRH3PTGESTAOK1TAOK3EPHX2 | |
| SCHEMBL6620401 | 0.87 | HRH3 (0.39) | HRH3PTGESTAOK1TAOK3EPHX2 | |
| SCHEMBL6619639 | 0.87 | DRD2 (0.43) | HRH3DRD2ADRA1AKDM4E | |
| SCHEMBL6620593 | 0.86 | HRH3 (0.39) | HRH3EPHX2 | |
| SCHEMBL6616321 | 0.86 | CHRNE (0.38) | DRD2ADRA1AEPHX2 | |
| SCHEMBL6620292 | 0.86 | PTGES (0.40) | DRD2ADRA1APTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |