Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDIA6 | Q15084 | 1/20 | 0.39 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5767535 | 0.75 | KDM4E (0.44) | ALDH1A1KDM4ECA1CA2CA7 | |
| SCHEMBL6643829 | 0.72 | CA2 (0.38) | CA1CA2CA7 | |
| SCHEMBL1094650 | 0.70 | CA2 (0.44) | CA1CA2CA7 | |
| SCHEMBL5795116 | 0.65 | PDIA6 (0.55) | PDIA6L3MBTL1ALDH1A1KDM4ECA1 | |
| SCHEMBL30266645 | 0.65 | PDIA6 (0.55) | PDIA6L3MBTL1ALDH1A1KDM4ECA1 | |
| SCHEMBL27497931 | 0.65 | KMT2A (0.64) | ALDH1A1KDM4ECA1CA2LMNA | |
| SCHEMBL23536145 | 0.63 | PDIA6 (0.53) | PDIA6L3MBTL1KDM4ECA1CA2 | |
| SCHEMBL1808292 | 0.63 | PDIA6 (0.53) | PDIA6L3MBTL1ALDH1A1KDM4ECA1 | |
| SCHEMBL1807019 | 0.63 | L3MBTL1 (0.70) | PDIA6L3MBTL1ALDH1A1KDM4ECA1 | |
| SCHEMBL12094098 | 0.63 | PDIA6 (0.53) | PDIA6L3MBTL1ALDH1A1KDM4ECA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461327-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2004-09-29 | — | — | EP | claimed |
| WO-2003044000-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2003-05-30 | — | — | WO | claimed |
| WO-2004113310-A1 | USE OF AN INHIBITOR OF 11-B-HYDROXYSTEROID DEHYDROGENASE TYPE 1 COMPOUNDS FOR PROMOTING WOUND HEALING | BIOVITRUM AB (SE) | 2004-12-29 | — | — | WO | disclosed |
| EP-1461327-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003044000-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2003-05-30 | — | — | WO | disclosed |