Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 5/20 | 0.51 |
| ▸ | CTSL | P07711 | 5/20 | 0.51 |
| ▸ | CTSK | P43235 | 4/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.43 |
| ▸ | PYGL | P06737 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.41 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.41 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.41 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463889 | 0.85 | CTSL (0.49) | CTSSCTSLCTSKCTSB | |
| SCHEMBL7462272 | 0.85 | CTSL (0.50) | CTSSCTSLCTSKTAS1R3TAS1R1 | |
| SCHEMBL7462346 | 0.85 | CTSK (0.47) | CTSSCTSLCTSKCTSB | |
| SCHEMBL7467137 | 0.85 | TAS1R3 (0.49) | CTSSCTSLCTSKTAS1R3TAS1R1 | |
| SCHEMBL6927425 | 0.85 | CTSL (0.55) | CTSSCTSLCTSKCTSB | |
| SCHEMBL7468998 | 0.84 | CTSK (0.65) | CTSSCTSLCTSKTAS1R3TAS1R1 | |
| SCHEMBL7467469 | 0.83 | CTSL (0.47) | CTSSCTSLCTSKCTSB | |
| SCHEMBL7467592 | 0.83 | TAS1R3 (0.49) | CTSSCTSLCTSKTAS1R3TAS1R1 | |
| SCHEMBL7473345 | 0.83 | TAS1R3 (0.54) | CTSSCTSLCTSKTAS1R3TAS1R1 | |
| SCHEMBL7467318 | 0.83 | CTSL (0.53) | CTSSCTSLCTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1067894-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-09-08 | — | — | EP | disclosed |
| US-6518267-B1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2003-02-11 | — | — | US | disclosed |
| EP-1067894-A2 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999059526-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-25 | — | — | WO | disclosed |