Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 7/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9205154 | 0.89 | KDM5A (0.54) | KDM5AKDM4CCDK2KDM4EALDH1A1 | |
| SCHEMBL5438939 | 0.79 | CDK2 (0.48) | KDM5AKDM4CCDK2KDM4EALDH1A1 | |
| SCHEMBL6624351 | 0.77 | KDM4E (0.57) | KDM5AKDM4CCDK2KDM4EALDH1A1 | |
| SCHEMBL18863648 | 0.76 | CDK2 (0.45) | KDM5AKDM4CCDK2KDM4EALDH1A1 | |
| SCHEMBL16050622 | 0.75 | CDK2 (0.51) | KDM5AKDM4CCDK2KDM4EALDH1A1 | |
| SCHEMBL4875792 | 0.74 | CDK2 (0.50) | KDM5AKDM4CCDK2KDM4EALDH1A1 | |
| SCHEMBL9215707 | 0.70 | DPP4 (0.34) | KDM5AKDM4CCDK2KDM4EALDH1A1 | |
| SCHEMBL9213889 | 0.69 | GSK3B (0.36) | KDM5AKDM4CCDK2KDM4EALDH1A1 | |
| SCHEMBL6624070 | 0.69 | KDM4E (0.49) | KDM5AKDM4CCDK2KDM4EALDH1A1 | |
| SCHEMBL5230928 | 0.69 | KDM4D (0.43) | CDK2KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0976754-B1 | REMEDIES/PREVENTIVES FOR RESPIRATORY DISEASES | POLA CHEM IND INC (JP) | 2004-07-14 | — | — | EP | disclosed |
| US-6329382-B1 | TREATMENT OF RESPIRATORY DISEASES | POLA CHEMICAL INDUSTRIES, INC. (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-0976754-A1 | REMEDIES/PREVENTIVES FOR RESPIRATORY DISEASES | POLA CHEMICAL INDUSTRIES, INC. (JP) | 2000-02-02 | — | — | EP | disclosed |