Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2831238 | 0.80 | CYP1A2 (0.38) | GAACA9MAOBMAPT | |
| SCHEMBL4243856 | 0.77 | CHRNB4 (0.49) | HRH3MAOB | |
| SCHEMBL6621672 | 0.75 | MMP2 (0.43) | HRH3ALDH1A1HRH2HRH1MMP2 | |
| SCHEMBL12133117 | 0.75 | ALDH1A1 (0.51) | HRH3GAASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL18920665 | 0.75 | CHRNB4 (0.44) | ALDH1A1 | |
| SCHEMBL105821 | 0.74 | ALDH1A3 (0.47) | HRH3GAASMN1; SMN2ALDH1A1CYP2A6 | |
| SCHEMBL8104625 | 0.73 | ALDH1A3 (0.58) | SMN1; SMN2ALDH1A1CYP2A6MAPT | |
| SCHEMBL18920686 | 0.73 | ALDH1A1 (0.37) | ALDH1A1MMP2 | |
| SCHEMBL12019955 | 0.73 | MEN1 (0.41) | HRH3GAASMN1; SMN2ALDH1A1HRH2 | |
| SCHEMBL11967027 | 0.72 | SMN1; SMN2 (0.51) | GAASMN1; SMN2ALDH1A1MAOBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047695-B1 | NOVEL BISPIDINE ANTIARRHYTHMIC COMPOUNDS | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | disclosed |
| US-6291475-B1 | 3,7-DIAZABICYCLO(3.3.1)NONANE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-09-18 | — | — | US | disclosed |