Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | MLYCD | O95822 | 1/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8279007 | 0.82 | GRM5 (0.45) | LOXL2KLKB1SIGMAR1ENPP2HTR2C | |
| Hydrochloric Acid SCHEMBL4934804 | 0.81 | GRM5 (0.44) | LOXL2ALDH1A1KLKB1SIGMAR1ENPP2 | |
| SCHEMBL27756954 | 0.81 | LOXL2 (0.43) | LOXL2ALDH1A1GLATSHRSIGMAR1 | |
| SCHEMBL31211562 | 0.78 | ALDH1A1 (0.63) | ALDH1A1GLATSHRMLYCDCYP3A4 | |
| SCHEMBL3510031 | 0.74 | ALDH1A1 (0.55) | LOXL2ALDH1A1TSHRENPP2NOS1 | |
| SCHEMBL27262066 | 0.72 | MEN1 (0.47) | ALDH1A1GLATSHRSIGMAR1HDAC8 | |
| SCHEMBL28141067 | 0.72 | LOXL2 (0.43) | LOXL2ALDH1A1TSHRENPP2NOS1 | |
| SCHEMBL9900076 | 0.72 | KLKB1 (0.41) | LOXL2TSHRKLKB1OPRM1OPRD1 | |
| SCHEMBL27763796 | 0.71 | THRA (0.49) | LOXL2ALDH1A1TSHROPRM1OPRD1 | |
| SCHEMBL27641824 | 0.71 | CRHBP (0.45) | LOXL2ALDH1A1TSHROPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487455-A1 | MORPHOLINE DERIVATIVES SUBSTITUTED AT THE 2-POSITION BY AN ARYLALKYLUREA GROUP FOR USE AS CCR-3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY CONDITIONS | GLAXO GROUP LIMITED (GB) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003082292-A1 | MORPHOLINE DERIVATIVES SUBSTITUTED AT THE 2-POSITION BY AN ARYLALKYLUREA GROUP FOR USE AS CCR-3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY CONDITIONS | GLAXO GROUP LIMITED (GB) | 2003-10-09 | — | — | WO | disclosed |