Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 2/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2157488 | 0.89 | CRHBP (0.45) | LTB4R2CRHBPCRHR2MEN1KMT2A | |
| SCHEMBL2158746 | 0.88 | LTB4R2 (0.52) | LTB4R2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL12464657 | 0.85 | LTB4R2 (0.50) | LTB4R2KMT2AALDH1A1HTTLMNA | |
| SCHEMBL2158624 | 0.80 | MEN1 (0.43) | LTB4R2MEN1KMT2AMAPT | |
| SCHEMBL3815444 | 0.79 | MEN1 (0.40) | LTB4R2CRHBPCRHR2MEN1KMT2A | |
| SCHEMBL12464655 | 0.77 | LTB4R2 (0.40) | LTB4R2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL12464386 | 0.76 | PTGDR2 (0.54) | LTB4R2MEN1KMT2AALDH1A1HTT | |
| SCHEMBL12464658 | 0.75 | LTB4R2 (0.39) | LTB4R2CYP2C9CYP2C19 | |
| SCHEMBL2157858 | 0.74 | TACR1 (0.40) | LTB4R2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL2158851 | 0.74 | LTB4R2 (0.48) | LTB4R2MEN1KMT2AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401825-A2 | THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS FOR FLAVIVIRUS INFECTION | Shire Biochem Inc. (CA) | 2004-03-31 | — | — | EP | disclosed |
| WO-2002100851-A2 | THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS FOR FLAVIVIRUS INFECTION | SHIRE BIOCHEM INC. (CA) | 2002-12-19 | — | — | WO | disclosed |