Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | STAT3 | P40763 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2158746 | 0.92 | LTB4R2 (0.52) | LTB4R2MAPTKMT2ASTAT3NPC1 | |
| SCHEMBL2158429 | 0.88 | LTB4R2 (0.47) | LTB4R2MAPTKMT2ACNR1STAT3 | |
| SCHEMBL2157845 | 0.87 | LTB4R2 (0.48) | LTB4R2MAPTKMT2ACNR1 | |
| SCHEMBL6625466 | 0.85 | LTB4R2 (0.47) | LTB4R2MAPTKMT2AALDH1A1HTT | |
| SCHEMBL12464655 | 0.85 | LTB4R2 (0.40) | LTB4R2MAPTKMT2ACNR1ALDH1A1 | |
| SCHEMBL12464648 | 0.80 | CPB1 (0.52) | MAPTKMT2ACNR1ALDH1A1HTT | |
| SCHEMBL12464386 | 0.79 | PTGDR2 (0.54) | LTB4R2KMT2ANPC1ALDH1A1HTT | |
| SCHEMBL2158029 | 0.79 | LTB4R2 (0.46) | LTB4R2MAPTKMT2ANPC1ALDH1A1 | |
| SCHEMBL12464387 | 0.78 | CNR2 (0.51) | MAPTKMT2ACNR1HTTCNR2 | |
| SCHEMBL12464658 | 0.78 | LTB4R2 (0.39) | LTB4R2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7985769-B2 | Compounds and methods for the treatment or prevention of Flavivirus infections | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-26 | — | — | US | disclosed |