Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2158059 | 0.89 | RIPK1 (0.40) | LTB4R2RIPK1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6629369 | 0.87 | ALDH1A1 (0.39) | LTB4R2RIPK1PTGDR2HCRTR1PTGER1 | |
| SCHEMBL2157748 | 0.87 | LTB4R2 (0.48) | LTB4R2RIPK1PTGDR2HCRTR1TP53 | |
| SCHEMBL2158006 | 0.86 | RIPK1 (0.41) | LTB4R2RIPK1PTGER1TP53 | |
| SCHEMBL2158746 | 0.82 | LTB4R2 (0.52) | LTB4R2PTGDR2 | |
| SCHEMBL12464655 | 0.82 | LTB4R2 (0.40) | LTB4R2SLC6A2SLC6A4SLC6A3PTGER1 | |
| SCHEMBL2157976 | 0.80 | MAPT (0.39) | SLC6A2SLC6A4SLC6A3TRPM8 | |
| SCHEMBL3809827 | 0.79 | MAPT (0.37) | LTB4R2RIPK1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12464439 | 0.78 | NOS1 (0.41) | PTGER1TP53 | |
| SCHEMBL12464657 | 0.78 | LTB4R2 (0.50) | LTB4R2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7985769-B2 | Compounds and methods for the treatment or prevention of Flavivirus infections | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-26 | — | — | US | disclosed |