Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.38 |
| ▸ | RAB9A | P51151 | 6/20 | 0.38 |
| ▸ | SYK | P43405 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6628178 | 0.86 | PDE10A (0.35) | TP53KDM4EMEN1KMT2AHTT | |
| SCHEMBL6625835 | 0.85 | GAA (0.33) | TP53NPC1RAB9ASYKKDM4E | |
| SCHEMBL9431441 | 0.72 | CYP2C19 (0.44) | TP53NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL6625483 | 0.70 | MEN1 (0.38) | TP53NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL6482032 | 0.66 | KDM4E (0.51) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL11048397 | 0.65 | PDGFRB (0.47) | NPC1RAB9AKDM4EMEN1KMT2A | |
| SCHEMBL1967426 | 0.65 | CLK4 (0.56) | NPC1RAB9ASYKKDM4ECYP19A1 | |
| SCHEMBL9255839 | 0.65 | MAPT (0.43) | NPC1RAB9AKDM4EMEN1KMT2A | |
| SCHEMBL10886759 | 0.64 | PDGFRB (0.46) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL12735602 | 0.63 | PDGFRB (0.50) | NPC1RAB9AKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004525942-A | — | — | 2004-08-26 | — | — | JP | claimed |
| US-20040116495-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2004-06-17 | — | — | US | claimed |
| EP-1379241-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2004-01-14 | — | — | EP | claimed |
| WO-2002078699-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | claimed |
| US-20040116495-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2004-06-17 | — | — | US | disclosed |