Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 9/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 8/20 | 0.32 |
| ▸ | SI | P14410 | 8/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 8/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6628178 | 0.89 | PDE10A (0.35) | KDM4EALDH1A1TP53LMNA | |
| SCHEMBL6625487 | 0.85 | TP53 (0.40) | GAAHPGDKDM4ENPC1ALDH1A1 | |
| SCHEMBL6625834 | 0.68 | MGAM (0.34) | GAAHSD17B10HPGDMGAMSI | |
| SCHEMBL6482032 | 0.68 | KDM4E (0.51) | KDM4ENPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL6629853 | 0.65 | HTT (0.50) | HPGDNPC1ALDH1A1TP53MAPT | |
| SCHEMBL7451163 | 0.63 | PDE10A (0.44) | GAAKDM4ENPC1MAPTRAB9A | |
| SCHEMBL1980545 | 0.62 | ALDH1A1 (0.38) | GAAHSD17B10HPGDKDM4ENPC1 | |
| SCHEMBL28079633 | 0.61 | NPC1 (0.42) | GAAKDM4ENPC1ALDH1A1TP53 | |
| SCHEMBL855275 | 0.61 | METAP2 (0.38) | GAAKDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL27834569 | 0.60 | HRH3 (0.45) | GAAHPGDKDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004525942-A | — | — | 2004-08-26 | — | — | JP | claimed |
| US-20040116495-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2004-06-17 | — | — | US | claimed |
| EP-1379241-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2004-01-14 | — | — | EP | claimed |
| WO-2002078699-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | claimed |
| US-20040116495-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2004-06-17 | — | — | US | disclosed |
| EP-1379241-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002078699-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | disclosed |