Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 6/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7238404 | 0.90 | LMNA (0.36) | LMNASMN1; SMN2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL6624038 | 0.90 | LMNA (0.36) | LMNASMN1; SMN2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL5239210 | 0.85 | HTR1A (0.37) | LMNASMN1; SMN2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL5234849 | 0.85 | HTR1A (0.37) | LMNASMN1; SMN2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL6625268 | 0.84 | LMNA (0.36) | LMNASMN1; SMN2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL6625266 | 0.84 | LMNA (0.36) | LMNASMN1; SMN2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL4375219 | 0.84 | HTR1A (0.47) | LMNASMN1; SMN2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL4372252 | 0.84 | HTR1A (0.47) | LMNASMN1; SMN2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL6628114 | 0.83 | LMNA (0.37) | LMNASMN1; SMN2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL6631935 | 0.83 | LMNA (0.37) | LMNASMN1; SMN2CYP3A4ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6656947-B2 | For therapy of depression, obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse | WYETH | 2003-12-02 | — | — | US | claimed |
| US-20020183341-A1 | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinazoline | WYETH (US) | 2002-12-05 | — | — | US | claimed |
| EP-1381612-A1 | ANTIDEPRESSANT AZA-HETEROCYCLYLMETHYL DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO[2,3-F]QUINAZOLINE | Wyeth (US) | 2004-01-21 | — | — | EP | disclosed |
| US-6656947-B2 | For therapy of depression, obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse | WYETH | 2003-12-02 | — | — | US | disclosed |
| US-20020183341-A1 | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinazoline | WYETH (US) | 2002-12-05 | — | — | US | disclosed |
| WO-2002088129-A1 | ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO[2,3-F]QUINAZOLINE | WYETH (US) | 2002-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183341-A1 | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinazoline | OPRD1, OPRK1, HTR2C | LMNA 4297/4885SMN1; SMN2 3519/4885CYP3A4 763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.