Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | GLS | O94925 | 2/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20474743 | 0.88 | HDAC6 (0.56) | MMP13NR1H4LMNAHPGDGLS | |
| SCHEMBL13999403 | 0.87 | ROCK2 (0.50) | MMP13NR1H4ROCK2ROCK1LMNA | |
| SCHEMBL13135999 | 0.85 | GLS (0.50) | MMP13NR1H4GLSKDM4ANAMPT | |
| SCHEMBL184425 | 0.85 | NR1H4 (0.61) | MMP13NR1H4GLSKDM4ANAMPT | |
| SCHEMBL879574 | 0.84 | LOXL2 (0.56) | MMP13NR1H4ROCK2ROCK1GLS | |
| SCHEMBL31044413 | 0.84 | GLS (0.49) | MMP13NR1H4GLSKDM4ANAMPT | |
| SCHEMBL6622954 | 0.83 | NAMPT (0.59) | NR1H4LMNANAMPTHDAC1HDAC8 | |
| SCHEMBL24140014 | 0.83 | ALDH1A1 (0.49) | MMP13NR1H4GLSKDM4ANAMPT | |
| SCHEMBL13862398 | 0.83 | LCK (0.53) | MMP13NR1H4ROCK2SMN1; SMN2HPGD | |
| SCHEMBL5564933 | 0.83 | SMYD3 (0.55) | NR1H4ROCK2ROCK1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487455-A1 | MORPHOLINE DERIVATIVES SUBSTITUTED AT THE 2-POSITION BY AN ARYLALKYLUREA GROUP FOR USE AS CCR-3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY CONDITIONS | GLAXO GROUP LIMITED (GB) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003082292-A1 | MORPHOLINE DERIVATIVES SUBSTITUTED AT THE 2-POSITION BY AN ARYLALKYLUREA GROUP FOR USE AS CCR-3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY CONDITIONS | GLAXO GROUP LIMITED (GB) | 2003-10-09 | — | — | WO | disclosed |