Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.69 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ANPEP | P15144 | 1/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.46 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7429456 | 0.88 | NPC1 (0.53) | EPHX1MMP2NPC1RAB9ATP53 | |
| SCHEMBL31633421 | 0.87 | ALDH1A1 (0.51) | EPHX1MMP2MEN1KMT2AALDH1A1 | |
| SCHEMBL27581400 | 0.85 | NPC1 (0.54) | EPHX1MMP2NPC1RAB9ATP53 | |
| SCHEMBL1516139 | 0.82 | EPHX1 (1.00) | EPHX1ALDH1A1CYP1A2 | |
| SCHEMBL6810144 | 0.82 | KMT2A (0.52) | EPHX1MMP2NPC1RAB9ATP53 | |
| SCHEMBL6810226 | 0.82 | KMT2A (0.52) | EPHX1MMP2NPC1RAB9ATP53 | |
| SCHEMBL8620330 | 0.81 | EPHX1 (0.96) | EPHX1MEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL27581401 | 0.79 | ESR1 (0.54) | EPHX1MMP2NPC1RAB9ATP53 | |
| SCHEMBL8117470 | 0.79 | EPHX1 (0.44) | EPHX1NPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL10991079 | 0.79 | ITGA4 (0.56) | EPHX1MMP2NPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377589-A1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-01-07 | — | — | EP | claimed |
| WO-2002062804-A1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2002-08-15 | — | — | WO | claimed |