Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | CDC25A | P30304 | 1/20 | 0.32 |
| ▸ | CDC25B | P30305 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | GPR3 | P46089 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27916062 | 0.76 | ALDH1A1 (0.35) | HSP90AA1HSP90AB1MITFALDH1A1MAPT | |
| SCHEMBL3922127 | 0.74 | GPR3 (0.46) | ALDH1A1GPR3POLB | |
| SCHEMBL27363609 | 0.72 | ALDH1A1 (0.39) | HSP90AA1HSP90AB1ALDH1A1MAPTCHRNB2 | |
| SCHEMBL6629142 | 0.71 | CDC25A (0.39) | HSP90AA1HSP90AB1MITFALDH1A1MAPT | |
| SCHEMBL232990 | 0.70 | LMNA (0.41) | ALDH1A1MAPTCHRNB2CHRNA4 | |
| SCHEMBL6633153 | 0.69 | MEN1 (0.38) | ALDH1A1MAPTPOLB | |
| SCHEMBL24119346 | 0.67 | MEN1 (0.44) | ALDH1A1MAPTHTTNPSR1CDC25A | |
| SCHEMBL6632251 | 0.66 | MAPT (0.43) | HSP90AA1HSP90AB1ALDH1A1MAPTNPSR1 | |
| SCHEMBL5837267 | 0.65 | GPR3 (0.46) | ALDH1A1GPR3POLB | |
| SCHEMBL3664412 | 0.65 | HTR2A (0.35) | MITFALDH1A1MAPTHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033130-B1 | INHIBITOR OF UROKINASE PRODUCTION AND OF ANGIOGENESIS AND ITS THERAPEUTIC USE | TAIHO PHARMACEUTICAL CO LTD (JP) | 2004-04-21 | — | — | EP | disclosed |
| US-6365610-B1 | 1,4-EPOXY-2,3-BENZODIOXEPINS OR 1,4-EPOXY-3,2-BENZOXAZEPINES | TAIHO PHARMACEUTICAL COMPANY LTD. (JP) | 2002-04-02 | — | — | US | disclosed |
| EP-1033130-A1 | UROKINASE PRODUCTION INHIBITORS, ANGIOGENESIS INHIBITORS AND METHODS OF PREVENTION OR TREATMENT WITH BOTH | TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) | 2000-09-06 | — | — | EP | disclosed |