Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 3/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.33 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6625142 | 1.00 | SLC6A9 (0.45) | SLC6A9HSD17B10ALBTACR1CACNA2D1 | |
| SCHEMBL5370149 | 1.00 | SLC6A9 (0.45) | SLC6A9HSD17B10ALBTACR1CACNA2D1 | |
| SCHEMBL5551081 | 1.00 | SLC6A9 (0.45) | SLC6A9HSD17B10ALBTACR1CACNA2D1 | |
| SCHEMBL6626285 | 0.90 | SLC6A9 (0.39) | SLC6A9HSD17B10ALBTACR1S1PR1 | |
| SCHEMBL21185731 | 0.87 | SLC6A9 (0.44) | SLC6A9HSD17B10ALBTACR1CACNA2D1 | |
| SCHEMBL300399 | 0.85 | — | — | |
| SCHEMBL9159811 | 0.85 | SLC6A9 (0.43) | SLC6A9HSD17B10ALBTACR1CACNA2D1 | |
| SCHEMBL6628233 | 0.85 | SLC6A9 (0.36) | SLC6A9HSD17B10ALBTACR1S1PR1 | |
| SCHEMBL15780321 | 0.85 | SLC6A9 (0.45) | SLC6A9HSD17B10ALBTACR1 | |
| SCHEMBL2779265 | 0.85 | SLC6A9 (0.45) | SLC6A9HSD17B10ALBTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0325762-B1 | Macrocyclic chelating agents and chelates thereof | BRACCO SPA (IT) | 1995-03-22 | — | — | EP | claimed |
| EP-0325762-A1 | Macrocyclic chelating agents and chelates thereof | BRACCO S.p.A. (IT) | 1989-08-02 | — | — | EP | claimed |
| EP-0998476-B1 | 1,4,7,10-TETRAAZABICYCLO 8.2.2]TETRADECAN-2-ONE, A PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF FOR THE PREPARATION OF TETRAAZAMACROCYCLES | BRACCO SPA (IT) | 2004-05-06 | — | — | EP | disclosed |
| US-6162912-A | Process of preparing tetraacetic acid derivatives | DIBRA S.P.A. (IT) | 2000-12-19 | — | — | US | disclosed |
| US-6048980-A | AMINATION WITH DEHYDROHALOGENATION FOLLOWED BY HYDROLYSIS OF ESTER GROUP | DIBRA S.P.A (IT) | 2000-04-11 | — | — | US | disclosed |
| US-6028194-A | SYNTHESIS OF GADOTERIDOL AND GADOBUTROL CONTRAST AGENTS FOR THE RESONANCE TECHNIQUE (MAGNETIC RESONANCE IMAGING) | DIBRA S.P.A. (IT) | 2000-02-22 | — | — | US | disclosed |
| US-6020485-A | Process for producing tetraazabicyclo monoacetic acid | DIBRA S.P.A. (IT) | 2000-02-01 | — | — | US | disclosed |
| US-5977353-A | 1,4,7,10-tetraazabicyclo[8.2.2]tetradecan-2-one, a process for the preparation thereof and the use thereof for the preparation of tetraazamacrocycles | DIBRA S.P.A. (IT) | 1999-11-02 | — | — | US | disclosed |
| EP-0325762-B1 | Macrocyclic chelating agents and chelates thereof | BRACCO SPA (IT) | 1995-03-22 | — | — | EP | disclosed |
| US-5132409-A | Derivatives of 1,4,7,10-Tetraazacyclododecane | BRACCO INDUSTRIA CHIMICA S.P.A. (IT) | 1992-07-21 | — | — | US | disclosed |
| EP-0325762-A1 | Macrocyclic chelating agents and chelates thereof | BRACCO S.p.A. (IT) | 1989-08-02 | — | — | EP | disclosed |