Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629424 | 0.81 | HTR7 (0.43) | KMT2APOLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6629479 | 0.77 | DRD1 (0.44) | MAPTMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL4553559 | 0.75 | QPCT (0.51) | MEN1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL19423161 | 0.74 | MAPT (0.53) | MAPTMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL6629684 | 0.73 | PDE4A (0.55) | POLBHSD17B10MAPK1TDP1PDE4A | |
| SCHEMBL7364822 | 0.71 | PDE4A (0.55) | MAPTMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL6628069 | 0.70 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20695860 | 0.69 | TUBB4A (0.53) | MAPTMEN1KMT2AL3MBTL1TSHR | |
| SCHEMBL19423102 | 0.69 | TUBB4A (0.53) | MAPTMEN1KMT2AL3MBTL1TSHR | |
| SCHEMBL13677704 | 0.69 | PDE4A (0.76) | MAPTKMT2AALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465630-A1 | CYCLIC UREA DERIVATIVES WITH 5-HT2C RECEPTOR ACTIVITY | GLAXO GROUP LIMITED (GB) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003057220-A1 | CYCLIC UREA DERIVATIVES WITH 5-HT2C RECEPTOR ACTIVITY | GLAXO GROUP LIMITED (GB) | 2003-07-17 | — | — | WO | disclosed |