Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 7/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6695509 | 0.76 | FAAH (0.40) | MAPTALDH1A1 | |
| SCHEMBL6630842 | 0.76 | MEN1 (0.44) | MEN1KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL6061605 | 0.76 | MEN1 (0.44) | MEN1KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL6690593 | 0.76 | FAAH (0.38) | RAB9AALDH1A1NPC1 | |
| SCHEMBL6061609 | 0.72 | MEN1 (0.47) | MEN1KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL6692777 | 0.67 | ATG4B (0.38) | MEN1KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL6631266 | 0.67 | ATG4B (0.38) | MEN1KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL6631267 | 0.67 | ATG4B (0.38) | MEN1KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL6630077 | 0.65 | ATG4B (0.44) | MEN1KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL6632107 | 0.62 | CTSS (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397340-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002098850-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | disclosed |