Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCPS | Q96C86 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CACNB4 | O00305 | 4/20 | 0.36 |
| ▸ | CACNA1A | O00555 | 4/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.36 |
| ▸ | CACNG3 | O60359 | 4/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.36 |
| ▸ | CACNB3 | P54284 | 4/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.36 |
| ▸ | CACNG7 | P62955 | 4/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.36 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.36 |
| ▸ | CACNB1 | Q02641 | 4/20 | 0.36 |
| ▸ | CACNG1 | Q06432 | 4/20 | 0.36 |
| ▸ | CACNB2 | Q08289 | 4/20 | 0.36 |
| ▸ | CACNA1S | Q13698 | 4/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6630676 | 0.82 | HTT (0.35) | DCPSPOLBF2R | |
| SCHEMBL6630767 | 0.75 | F2R (0.46) | DCPSF2R | |
| SCHEMBL6795053 | 0.71 | F2R (0.48) | DCPSKDM4EALDH1A1F2R | |
| SCHEMBL6630874 | 0.69 | TRPM5 (0.35) | KDM4EALDH1A1POLB | |
| SCHEMBL30596550 | 0.64 | KDM4E (0.70) | KDM4EALDH1A1POLBCYP2A13HRH3 | |
| SCHEMBL14583991 | 0.63 | SLC22A12 (0.56) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL21497073 | 0.63 | DHFR (0.49) | DCPS | |
| SCHEMBL29669166 | 0.60 | KDM4E (0.58) | KDM4EALDH1A1POLBCYP2A13RAB9A | |
| SCHEMBL20238189 | 0.60 | KDM4E (0.58) | KDM4EALDH1A1POLBCYP2A13RAB9A | |
| SCHEMBL2107499 | 0.59 | ALDH1A1 (0.96) | KDM4EALDH1A1POLBCYP2A13RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370560-B1 | AMINOMETHYL-PYRROLOQUINAZOLINE COMPOUNDS AS THROMBIN RECEPTOR ANTAGONISTS | ORTHO MCNEIL PHARM INC (US) | 2004-11-10 | — | — | EP | claimed |
| US-6740657-B2 | FOR EXAMPLE, N3-CYCLOPROPYL-7-((2,6-DICHLOROPHENYL)METHYL)-9-((DIMETHYLAMINO)METHYL)-7H -PYRROLO(3,2-F) QUINAZOLINE-1,3-DIAMI NE; TREATING CARDIOVASCULAR DISORDERS, RESTENOSIS, THROMBOSIS, AND OTHER DISORDERS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-05-25 | — | — | US | claimed |
| US-20020160963-A1 | Aminomethyl-pyrroloquinazoline compounds as thrombin receptor antagonists | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-10-31 | — | — | US | claimed |
| EP-1370560-B1 | AMINOMETHYL-PYRROLOQUINAZOLINE COMPOUNDS AS THROMBIN RECEPTOR ANTAGONISTS | ORTHO MCNEIL PHARM INC (US) | 2004-11-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020160963-A1 | Aminomethyl-pyrroloquinazoline compounds as thrombin receptor antagonists | F2R, F2RL1, F2RL3 | DCPS 1532/4885KDM4E 2554/4885ALDH1A1 4042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.