Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27274014 | 0.83 | FBP1 (0.39) | SIRT1ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL3077375 | 0.80 | SIRT1 (0.77) | SIRT1ALDH1A1MAPTKDM4EHSD17B10 | |
| SCHEMBL6633843 | 0.76 | SIRT1 (0.53) | SIRT1ALDH1A1MAPTKDM4EHSD17B10 | |
| SCHEMBL7701766 | 0.74 | SIRT1 (0.54) | SIRT1ALDH1A1MAPTKDM4EHSD17B10 | |
| SCHEMBL6633964 | 0.74 | SIRT1 (0.54) | SIRT1ALDH1A1MAPTKDM4EHSD17B10 | |
| SCHEMBL1030659 | 0.73 | SIRT1 (1.00) | SIRT1ALDH1A1MAPTKDM4EHSD17B10 | |
| SCHEMBL11821622 | 0.72 | SIRT1 (0.64) | SIRT1ALDH1A1MAPTKDM4EHSD17B10 | |
| SCHEMBL29530768 | 0.72 | SIRT1 (0.64) | SIRT1ALDH1A1MAPTKDM4EHSD17B10 | |
| SCHEMBL1399456 | 0.72 | SIRT1 (0.64) | SIRT1ALDH1A1MAPTKDM4EHSD17B10 | |
| SCHEMBL6629741 | 0.72 | SIRT1 (0.65) | SIRT1ALDH1A1MAPTKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480977-A2 | SUBSTITUTED ARYL COMPOUNDS FOR TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-12-01 | — | — | EP | claimed |
| WO-2003070728-A2 | AZABICYCLO-SUBSTITUTED BENZOYLAMIDES AND THIOAMIDES FOR TREATMENT OF CNS-RELATED DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 2003-08-28 | — | — | WO | claimed |
| WO-2002016357-A2 | QUINUCLIDINE-SUBSTITUTED ARYL MOIETIES FOR TREATMENT OF DISEASE (NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS) | PHARMACIA & UPJOHN COMPANY (US) | 2002-02-28 | — | — | WO | claimed |