Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6633964 | 0.81 | SIRT1 (0.54) | SIRT1ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL7707377 | 0.78 | SIRT1 (0.50) | SIRT1ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL3077375 | 0.77 | SIRT1 (0.77) | SIRT1ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL8098736 | 0.75 | ALDH1A1 (0.44) | ALDH1A1KDM4EMAPTHSD17B10TSHR | |
| SCHEMBL6629448 | 0.74 | SIRT1 (0.57) | SIRT1ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL11334883 | 0.72 | SIRT1 (0.74) | SIRT1ALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL6633843 | 0.71 | SIRT1 (0.53) | SIRT1ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL1030659 | 0.71 | SIRT1 (1.00) | SIRT1ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL7418361 | 0.70 | SIRT1 (0.60) | SIRT1ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL29530768 | 0.69 | SIRT1 (0.64) | SIRT1ALDH1A1KDM4EHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002016357-A2 | QUINUCLIDINE-SUBSTITUTED ARYL MOIETIES FOR TREATMENT OF DISEASE (NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS) | PHARMACIA & UPJOHN COMPANY (US) | 2002-02-28 | — | — | WO | claimed |