Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | IDE | P14735 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6625661 | 0.82 | PDPK1 (0.39) | KMT2ASMN1; SMN2IDELMNAPOLB | |
| SCHEMBL2157530 | 0.81 | POLB (0.39) | KMT2AMEN1POLBMAPTTP53 | |
| SCHEMBL3812670 | 0.79 | TP53 (0.34) | KMT2ASMN1; SMN2LMNAPOLBMAPT | |
| SCHEMBL2158006 | 0.78 | RIPK1 (0.41) | KMT2AMEN1TP53PTGER1L3MBTL1 | |
| SCHEMBL2157926 | 0.77 | RAB9A (0.39) | MAPK8KMT2AMEN1SMN1; SMN2IDE | |
| SCHEMBL2158024 | 0.77 | MC4R (0.41) | MAPK8SMN1; SMN2IDELMNAPOLB | |
| SCHEMBL6629855 | 0.76 | SMN1; SMN2 (0.36) | KMT2AMEN1SMN1; SMN2IDELMNA | |
| SCHEMBL6629369 | 0.76 | ALDH1A1 (0.39) | KMT2AMEN1HCRTR1POLBTP53 | |
| SCHEMBL2157748 | 0.76 | LTB4R2 (0.48) | KMT2AMEN1HCRTR1TP53PTGDR2 | |
| SCHEMBL2158059 | 0.76 | RIPK1 (0.40) | KMT2AMEN1TP53KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401825-A2 | THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS FOR FLAVIVIRUS INFECTION | Shire Biochem Inc. (CA) | 2004-03-31 | — | — | EP | disclosed |
| WO-2002100851-A2 | THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS FOR FLAVIVIRUS INFECTION | SHIRE BIOCHEM INC. (CA) | 2002-12-19 | — | — | WO | disclosed |