Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSPO | P30536 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2157748 | 0.88 | LTB4R2 (0.48) | MEN1KMT2ALTB4R2PTGDR2RIPK1 | |
| SCHEMBL2158006 | 0.87 | RIPK1 (0.41) | MEN1KMT2ALTB4R2RIPK1PTGER1 | |
| SCHEMBL12464658 | 0.87 | LTB4R2 (0.39) | LTB4R2PTGDR2RIPK1PTGER1HCRTR1 | |
| SCHEMBL2158059 | 0.85 | RIPK1 (0.40) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL2158771 | 0.82 | KMT2A (0.46) | ALDH1A1MEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL2157495 | 0.81 | KDM4E (0.39) | ALDH1A1MEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL3809662 | 0.80 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL12464439 | 0.79 | NOS1 (0.41) | PTGER1POLBTP53 | |
| SCHEMBL6629583 | 0.76 | MAPK8 (0.35) | ALDH1A1MEN1KMT2AKDM4ETSHR | |
| SCHEMBL2157674 | 0.71 | PTGDR2 (0.42) | ALDH1A1MEN1KMT2AKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401825-A2 | THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS FOR FLAVIVIRUS INFECTION | Shire Biochem Inc. (CA) | 2004-03-31 | — | — | EP | disclosed |
| WO-2002100851-A2 | THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS FOR FLAVIVIRUS INFECTION | SHIRE BIOCHEM INC. (CA) | 2002-12-19 | — | — | WO | disclosed |