Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | YWHAG | P61981 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6631182 | 0.78 | HDAC2 (0.48) | KDM4EMEN1MAPTTHRBALOX15 | |
| SCHEMBL11217216 | 0.76 | HSD17B10 (0.53) | KDM4EMEN1MAPTTHRBALOX15 | |
| SCHEMBL4916238 | 0.75 | HTR7 (0.44) | MAPTCHEK1MTORALDH1A1SMN1; SMN2 | |
| SCHEMBL22542062 | 0.74 | KDM4E (0.51) | KDM4EMEN1MAPTTHRBALOX15 | |
| SCHEMBL3568654 | 0.72 | KCNH2 (0.61) | ACMSDKDM4EMAPTGFERKMT2A | |
| SCHEMBL6605568 | 0.72 | HTR7 (0.51) | CHEK1HTR6 | |
| SCHEMBL20883677 | 0.71 | KDM4E (0.48) | KDM4EMEN1MAPTTHRBALOX15 | |
| SCHEMBL6627618 | 0.71 | ADRB2 (0.49) | KDM4EMEN1MAPTTHRBALOX15 | |
| SCHEMBL3468316 | 0.71 | ACMSD (0.54) | ACMSDMAPTCHEK1CHEK2ALDH1A1 | |
| SCHEMBL3898554 | 0.71 | ACMSD (0.45) | ACMSDMEN1MAPTKMT2ACHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1389194-A2 | INHIBITORS OF BACE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-02-18 | — | — | EP | disclosed |
| WO-2002088101-A2 | INHIBITORS OF BACE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2002-11-07 | — | — | WO | disclosed |