Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.53 |
| ▸ | HTR2A | P28223 | 9/20 | 0.53 |
| ▸ | HTR2C | P28335 | 9/20 | 0.53 |
| ▸ | HTR2B | P41595 | 9/20 | 0.53 |
| ▸ | DRD2 | P14416 | 9/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6112888 | 0.90 | SIGMAR1 (0.46) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL1793005 | 0.81 | L3MBTL1 (0.46) | SIGMAR1HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL29498104 | 0.81 | L3MBTL1 (0.46) | SIGMAR1HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL8000235 | 0.81 | SIGMAR1 (0.49) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| Hydrochloric Acid SCHEMBL6600350 | 0.80 | L3MBTL1 (0.45) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL15903298 | 0.79 | SIGMAR1 (0.50) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL3054003 | 0.76 | SIGMAR1 (0.57) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL29447988 | 0.76 | SIGMAR1 (0.57) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL11242114 | 0.75 | SIGMAR1 (0.53) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL14358027 | 0.74 | SIGMAR1 (0.56) | SIGMAR1HTR2AHTR2CHTR2BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101885674-A | Preparation method of 5,8-dimethoxy-2-tetralin ketone | GANSU HAOTIAN CHEMEXPRESS CO LTD | 2010-11-17 | — | — | CN | disclosed |
| CN-1209353-C | Estrogen agonist/antagonist metabolites | PFIZER PROD INC (US) | 2005-07-06 | — | — | CN | disclosed |
| EP-0942722-B1 | TETRAHYDRO-BETA-CARBOLINE COMPOUNDS | LILLY CO ELI (US) | 2004-05-19 | — | — | EP | disclosed |
| CN-1137085-C | Process for preparation of 5,6-dihydroxyl-2-amino-1,2,3,4-tetrahydronaphthalene derivatives | ������˹ҩƷ��˾ | 2004-02-04 | — | — | CN | disclosed |
| CN-1422263-A | Estrogen agonist/antagonist metabolites | PFIZER PROD INC (US) | 2003-06-04 | — | — | CN | disclosed |
| EP-0942722-A4 | TETRAHYDRO-BETA-CARBOLINE COMPOUNDS | LILLY CO ELI (US) | 2002-06-05 | — | — | EP | disclosed |
| CN-1073984-C | Process for preparing 5, 6-dihydroxy-2-amino-1, 2,3, 4-tetrahydronaphthalene derivatives | CHIESI FARMA SPA (IT) | 2001-10-31 | — | — | CN | disclosed |
| CN-1278526-A | Process for preparation of 5,6-dihydroxyl-2-amino-1,2,3,4-tetrahydronaphthalene derivatives | CHIESI PHARMACEUTICAL S P A (IT) | 2001-01-03 | — | — | CN | disclosed |
| CN-1278527-A | Process for preparation of 5,6-dihydrxyl-2-amino-1,2,3,4-tetrahydronaphthalene derivatives | CHIESI PHARMACEUTICAL S P A (IT) | 2001-01-03 | — | — | CN | disclosed |
| CN-1278528-A | Process for preparation of 5,6-dihydroxyl-2-amino-1,2,3,4-tetrahydronaphthalene derivatives | CHIESI PHARMACEUTICAL S P A (IT) | 2001-01-03 | — | — | CN | disclosed |
| WO-1997035578-A1 | TETRAHYDRO-BETA-CARBOLINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 1997-10-02 | — | — | WO | disclosed |
| WO-1997035479-A1 | METHODS OF TREATING VENOMOUS BITES AND STINGS | ELI LILLY AND COMPANY (US) | 1997-10-02 | — | — | WO | disclosed |
| EP-0797995-A2 | Use of a 5-HT2 receptor antagonist in the manufacture of a medicament for treating or ameliorating the symptoms of common cold or allergic rhinitis | ELI LILLY AND COMPANY (US) | 1997-10-01 | — | — | EP | disclosed |
| EP-0797994-A2 | Use of one or more 5-HT2 receptor antagonists in the manufacture of a medicament for treating the symptoms of venomous bites and stings | ELI LILLY AND COMPANY (US) | 1997-10-01 | — | — | EP | disclosed |
| CN-1147808-A | Process for preparing 5, 6-dihydroxy-2-amino-1, 2, 3, 4-tetrahydronaphthalene derivatives | CHIESI FARMA SPA (IT) | 1997-04-16 | — | — | CN | disclosed |
| CN-1124489-A | Tetracyclic compounds as dopamine agonists | ABBOTT LAB (US) | 1996-06-12 | — | — | CN | disclosed |
| EP-0343830-B1 | Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes | LILLY CO ELI (US) | 1994-07-13 | — | — | EP | disclosed |
| WO-1994007863-A1 | OCTAHYDRONAPHTHOQUINOLIZINES, AND METHODS OF MAKING AND USING THEREOF | NEW YORK UNIVERSITY (US) | 1994-04-14 | — | — | WO | disclosed |
| US-5026707-A | Antiserotonine agents | ELI LILLY AND COMPANY (US) | 1991-06-25 | — | — | US | disclosed |
| EP-0343830-A2 | Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes | ELI LILLY AND COMPANY (US) | 1989-11-29 | — | — | EP | disclosed |