SCHEMBL6629690

SCHEMBL6629690

Cc1cc(C)n2nc(NS(=O)(=O)c3cccs3)nc2n1

nearest known ligand 0.54

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.54
TSHR P16473 4/20 0.54
ALDH1A1 P00352 6/20 0.52
HPGD P15428 5/20 0.52
HSD17B10 Q99714 4/20 0.52
POLB P06746 2/20 0.50
GLA P06280 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
USP2 O75604 1/20 0.47
PDE10A Q9Y233 1/20 0.46
KMT2A Q03164 2/20 0.45
HTT P42858 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8376128 0.77 ALDH1A1 (0.53) KDM4ETSHRALDH1A1HPGDHSD17B10
SCHEMBL8356883 0.73 SMN1; SMN2 (0.50) KDM4ETSHRALDH1A1HPGDHSD17B10
SCHEMBL8355499 0.73 POLB (0.52) KDM4ETSHRALDH1A1HPGDHSD17B10
SCHEMBL4065984 0.71 KDM4E (0.51) KDM4ETSHRALDH1A1HPGDHSD17B10
SCHEMBL13016767 0.68 HTR6 (0.69)
SCHEMBL4477891 0.68 ALDH1A1 (0.60) KDM4ETSHRALDH1A1HPGDHSD17B10
SCHEMBL9832114 0.68 TSHR (0.66) KDM4ETSHRALDH1A1HPGDHSD17B10
SCHEMBL4072266 0.68 RAB9A (0.55) KDM4ETSHRALDH1A1HPGDHSD17B10
SCHEMBL8045699 0.68 HTR6 (0.71)
SCHEMBL8840340 0.67 KDM4E (0.69) KDM4ETSHRALDH1A1HPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0565593-A1 REDUCING PESTICIDAL INTERACTIONS IN CROPS MONSANTO COMPANY (US) 1993-10-20 EP claimed
EP-0562015-A1 SAFENED HERBICIDAL SULFONAMIDE COMPOSITIONS MONSANTO COMPANY (US) 1993-09-29 EP claimed
WO-1992011761-A1 REDUCING PESTICIDAL INTERACTIONS IN CROPS MONSANTO COMPANY (US) 1992-07-23 WO claimed
WO-1992010098-A1 SAFENED HERBICIDAL SULFONAMIDE COMPOSITIONS MONSANTO COMPANY (US) 1992-06-25 WO claimed
EP-1242425-B1 N-(5,7-DIMETHOXY[1,2,4]TRIAZOLO[1,5-a]PYRIMIDIN-2-YL) ARYLSULFONAMIDE COMPOUNDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2004-03-03 EP disclosed
US-5880066-A COMPOSITION COMPRISING TRIAZOLOPYRIMIDINE SULFONAMIDE HERBICIDE AND OXAZOLIDINE DICHLOROACETAMIDE ANTIDOTE MONSANTO COMPANY (US) 1999-03-09 US disclosed
EP-0565593-B1 REDUCING PESTICIDAL INTERACTIONS IN CROPS MONSANTO CO (US) 1999-03-03 EP disclosed
EP-0603240-B1 SAFENING HERBICIDAL PYRAZOLYLSULFONYLUREAS MONSANTO CO (US) 1998-12-02 EP disclosed
US-5502025-A ANTIDOTES FOR HERBICIDES AND PLANT SAFTENING AGENTS MONSANTO COMPANY (US) 1996-03-26 US disclosed
US-5484760-A AMIDES MONSANTO COMPANY (US) 1996-01-16 US disclosed
EP-0565593-A1 REDUCING PESTICIDAL INTERACTIONS IN CROPS MONSANTO COMPANY (US) 1993-10-20 EP disclosed
EP-0562015-A1 SAFENED HERBICIDAL SULFONAMIDE COMPOSITIONS MONSANTO COMPANY (US) 1993-09-29 EP disclosed
EP-0531271-A1 Safening herbicidal pyrazolysulfonylureas MONSANTO COMPANY (US) 1993-03-10 EP disclosed
WO-1992011761-A1 REDUCING PESTICIDAL INTERACTIONS IN CROPS MONSANTO COMPANY (US) 1992-07-23 WO disclosed
WO-1992010098-A1 SAFENED HERBICIDAL SULFONAMIDE COMPOSITIONS MONSANTO COMPANY (US) 1992-06-25 WO disclosed
US-4822404-A HERBICIDES THE DOW CHEMICAL COMPANY (US) 1989-04-18 US disclosed
US-4822404-A HERBICIDES THE DOW CHEMICAL COMPANY (US) 1989-04-18 US disclosed
EP-0150974-A2 Novel sulfonamides derived from substituted 2-amino-1,2,4-triazolo(1,5-a)pyrimidines and compositions and methods of controlling undesired vegetation THE DOW CHEMICAL COMPANY (US) 1985-08-07 EP disclosed
EP-0150974-A2 Novel sulfonamides derived from substituted 2-amino-1,2,4-triazolo(1,5-a)pyrimidines and compositions and methods of controlling undesired vegetation THE DOW CHEMICAL COMPANY (US) 1985-08-07 EP disclosed