Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30398570 | 0.89 | HRH3 (0.55) | HRH3CYP1A2CYP2D6KDM4EL3MBTL1 | |
| SCHEMBL487617 | 0.89 | HRH3 (0.55) | HRH3CYP1A2CYP2D6KDM4EL3MBTL1 | |
| SCHEMBL5737703 | 0.84 | HRH3 (0.43) | HRH3CYP1A2CYP2D6KDM4EL3MBTL1 | |
| SCHEMBL27674580 | 0.83 | HRH3 (0.60) | HRH3CYP1A2CYP2D6KDM4EL3MBTL1 | |
| SCHEMBL2600004 | 0.78 | HRH3 (0.50) | HRH3CYP1A2CYP2D6KDM4EL3MBTL1 | |
| SCHEMBL14389059 | 0.78 | HRH3 (0.50) | HRH3CYP1A2CYP2D6KDM4EL3MBTL1 | |
| SCHEMBL2380517 | 0.78 | HRH3 (0.50) | HRH3CYP1A2CYP2D6KDM4EL3MBTL1 | |
| SCHEMBL12763633 | 0.78 | HRH3 (0.50) | HRH3CYP1A2CYP2D6KDM4EL3MBTL1 | |
| SCHEMBL13401237 | 0.78 | HRH3 (0.50) | HRH3CYP1A2CYP2D6KDM4EL3MBTL1 | |
| SCHEMBL12441410 | 0.78 | HRH3 (0.50) | HRH3CYP1A2CYP2D6KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2471782-A1 | NOVEL SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME | Kowa Company, Ltd. (JP) | 2012-07-04 | — | — | EP | disclosed |
| US-20120122906-A1 | NOVEL SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME | KOWA COMPANY, LTD. (JP) | 2012-05-17 | — | — | US | disclosed |
| US-20120046308-A1 | NOVEL ALPHA-PHENOXYBENZENEACETIC ACID DERIVATIVE AND PHARMACEUTICAL PREPARATION COMPRISING SAME | KOWA COMPANY, LTD. (JP) | 2012-02-23 | — | — | US | disclosed |
| US-7922317-B2 | Ink jet printing apparatus, data generation apparatus and printed product | CANON KABUSHIKI KAISHA (JP) | 2011-04-12 | — | — | US | disclosed |
| US-20090216024-A1 | Processes for making pioglitazone and compounds of the processes | ZHU JIE | 2009-08-27 | — | — | US | disclosed |
| US-7541470-B2 | Processes for making pioglitazone and compounds of the processes | SYNTHON IP INC. (US) | 2009-06-02 | — | — | US | disclosed |
| EP-1053227-B1 | PPAR-GAMMA MODULATORS | AMGEN INC (US) | 2008-11-05 | — | — | EP | disclosed |
| US-7439242-B2 | PPARγ modulators | AMGEN INC. (US) | 2008-10-21 | — | — | US | disclosed |
| US-20070291071-A1 | INK JET PRINTING APPARATUS, DATA GENERATION APPARATUS AND PRINTED PRODUCT | CANON KABUSHIKI KAISHA (JP) | 2007-12-20 | — | — | US | disclosed |
| US-20070167629-A1 | Processes for making pioglitazone and compounds of the processes | SYNTHON IP INC. | 2007-07-19 | — | — | US | disclosed |
| US-20050043360-A1 | Method for obtaining pioglitazone as an antidiabetic agent | LECIVA, A.S. (CZ) | 2005-02-24 | — | — | US | disclosed |
| US-6848781-B2 | Image forming process, image-recorded article, liquid composition and ink-jet recording apparatus | CANON KABUSHIKI KAISHA (JP) | 2005-02-01 | — | — | US | disclosed |
| US-20040135864-A1 | Image forming process, image-recorded article, liquid composition and ink-jet recording apparatus | CANON KABUSHIKI KAISHA (JP) | 2004-07-15 | — | — | US | disclosed |
| EP-1403088-A1 | Image forming process, image-recorded article, liquid composition and ink-jet recording apparatus | CANON KABUSHIKI KAISHA (JP) | 2004-03-31 | — | — | EP | disclosed |
| EP-1387843-A1 | METHOD FOR OBTAINING PIOGLITAZONE AS AN ANTIDIABETIC AGENT | Leciva, A.S. (CZ) | 2004-02-11 | — | — | EP | disclosed |
| US-6620827-B2 | Peroxisome proliferator-activated receptors-gamma to control lipid metabolism ane obesity; antidiabetic, -inflammatory and -arthritic agents; non-insulin dependent diabetes; antilipemic and -cholesterol agents | TULARIK INC. | 2003-09-16 | — | — | US | disclosed |
| WO-2002088120-A1 | METHOD FOR OBTAINING PIOGLITAZONE AS AN ANTIDIABETIC AGENT | Léciva, a.s. (CZ) | 2002-11-07 | — | — | WO | disclosed |
| US-6200995-B1 | PYRIDYLOXYBENZENESULFONAMIDE DERIVATIVES; DIABETES, OBESITY | TULARIK INC. | 2001-03-13 | — | — | US | disclosed |
| EP-1053227-A1 | PPAR-GAMMA MODULATORS | TULARIK, INC. (US) | 2000-11-22 | — | — | EP | disclosed |
| WO-1999038845-A1 | PPAR-GAMMA MODULATORS | TULARIK INC. (US) | 1999-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090216024-A1 | Processes for making pioglitazone and compounds of the processes | PDK4, PDK2, DPP4 | HRH3 4492/4885CYP1A2 754/4885CYP2D6 269/4885 |
| US-20120122906-A1 | NOVEL SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME | AGTR2, AGTR1, PPARA | HRH3 1472/4885CYP1A2 1901/4885CYP2D6 1650/4885 |
| US-20070167629-A1 | Processes for making pioglitazone and compounds of the processes | PDK4, PDK2, DPP4 | HRH3 4492/4885CYP1A2 754/4885CYP2D6 269/4885 |
| US-20120046308-A1 | NOVEL ALPHA-PHENOXYBENZENEACETIC ACID DERIVATIVE AND PHARMACEUTICAL PREPARATION COMPRISING SAME | PPARA, PPARG, PPARD | HRH3 819/4885CYP1A2 669/4885CYP2D6 419/4885 |
| US-20050043360-A1 | Method for obtaining pioglitazone as an antidiabetic agent | GLP1R, INSR, CBR3 | HRH3 732/4885CYP1A2 1504/4885CYP2D6 969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.