Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 16/20 | 0.80 |
| ▸ | MMP2 | P08253 | 7/20 | 0.80 |
| ▸ | MMP3 | P08254 | 6/20 | 0.80 |
| ▸ | MMP9 | P14780 | 6/20 | 0.80 |
| ▸ | MMP1 | P03956 | 6/20 | 0.80 |
| ▸ | MMP7 | P09237 | 4/20 | 0.80 |
| ▸ | MMP8 | P22894 | 4/20 | 0.80 |
| ▸ | MMP13 | P45452 | 4/20 | 0.80 |
| ▸ | MMP14 | P50281 | 4/20 | 0.80 |
| ▸ | ADAM10 | O14672 | 4/20 | 0.80 |
| ▸ | ADAM33 | Q9BZ11 | 2/20 | 0.67 |
| ▸ | MMP15 | P51511 | 1/20 | 0.67 |
| ▸ | MMP16 | P51512 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6681285 | 1.00 | ADAM17 (0.80) | ADAM17MMP2MMP3MMP9MMP1 | |
| Trifluoroacetic Acid SCHEMBL6628784 | 0.96 | ADAM17 (0.74) | ADAM17MMP2MMP3MMP9MMP1 | |
| SCHEMBL1021287 | 0.89 | ADAM17 (1.00) | ADAM17MMP2MMP3MMP9MMP1 | |
| SCHEMBL6350415 | 0.89 | ADAM17 (1.00) | ADAM17MMP2MMP3MMP9MMP1 | |
| SCHEMBL29732231 | 0.89 | ADAM17 (1.00) | ADAM17MMP2MMP3MMP9MMP1 | |
| SCHEMBL6350418 | 0.89 | ADAM17 (1.00) | ADAM17MMP2MMP3MMP9MMP1 | |
| SCHEMBL6681213 | 0.81 | ADAM17 (0.86) | ADAM17MMP2MMP3MMP9MMP1 | |
| SCHEMBL2834283 | 0.80 | ADAM17 (1.00) | ADAM17MMP2MMP3MMP9MMP1 | |
| SCHEMBL5966106 | 0.80 | ADAM17 (1.00) | ADAM17MMP2MMP3MMP9MMP1 | |
| SCHEMBL6692506 | 0.80 | ADAM17 (1.00) | ADAM17MMP2MMP3MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040120977-A1 | Anti-inflammatory coatings for implantable medical devices and devices containing said coatings | BRISTOL-MYERS SQUIBB COMPANY | 2004-06-24 | — | — | US | claimed |
| EP-1027332-B1 | NOVEL LACTAM METALLOPROTEASE INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2004-05-26 | — | — | EP | claimed |
| US-20030225054-A1 | Combined use of tace inhibitors and COX2 inhibitors as anti-inflammatory agents | BRISTOL-MYERS SQUIBB COMPANY | 2003-12-04 | — | — | US | claimed |
| US-20030134827-A1 | Novel lactam metalloprotease inhibitors | DUAN JINGWU (US) | 2003-07-17 | — | — | US | claimed |
| EP-1490341-A1 | NOVEL ADAMANTANE DERIVATIVES | AstraZeneca AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| US-20040120977-A1 | Anti-inflammatory coatings for implantable medical devices and devices containing said coatings | BRISTOL-MYERS SQUIBB COMPANY | 2004-06-24 | — | — | US | disclosed |
| EP-1027332-B1 | NOVEL LACTAM METALLOPROTEASE INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2004-05-26 | — | — | EP | disclosed |
| US-20030225054-A1 | Combined use of tace inhibitors and COX2 inhibitors as anti-inflammatory agents | BRISTOL-MYERS SQUIBB COMPANY | 2003-12-04 | — | — | US | disclosed |
| WO-2003080579-A1 | NOVEL ADAMANTANE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-10-02 | — | — | WO | disclosed |
| US-6610731-B2 | Antiinflammatory | BRISTOL-MYERS SQUIBB COMPANY | 2003-08-26 | — | — | US | disclosed |
| US-20030134827-A1 | Novel lactam metalloprotease inhibitors | DUAN JINGWU (US) | 2003-07-17 | — | — | US | disclosed |
| US-6403632-B1 | CYCLIC AMIDE DERIVATIVE | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2002-06-11 | — | — | US | disclosed |
| EP-1027332-A1 | NOVEL LACTAM METALLOPROTEASE INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2000-08-16 | — | — | EP | disclosed |
| US-6057336-A | ANTIINFLAMMATORY AGENTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2000-05-02 | — | — | US | disclosed |
| WO-1999018074-A1 | NOVEL LACTAM METALLOPROTEASE INHIBITORS | Britol-Myers Squibb Pharma Company (US) | 1999-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030134827-A1 | Novel lactam metalloprotease inhibitors | ADAM9, ADAM8, ADAM17 | ADAM17 3/4885MMP2 10/4885MMP3 11/4885 |
| US-20030225054-A1 | Combined use of tace inhibitors and COX2 inhibitors as anti-inflammatory agents | TNF, PTGS1, MIF | ADAM17 64/4885MMP2 46/4885MMP3 31/4885 |
| US-20040120977-A1 | Anti-inflammatory coatings for implantable medical devices and devices containing said coatings | TNF, MIF, MMP12 | ADAM17 13/4885MMP2 53/4885MMP3 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.