Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.68 |
| ▸ | KIF11 | P52732 | 1/20 | 0.60 |
| ▸ | LSS | P48449 | 1/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 2/20 | 0.54 |
| ▸ | PPARA | Q07869 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | MLYCD | O95822 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28095336 | 0.83 | HPGD (0.72) | MAPK14EPHX2NR1H4NPC1RAB9A | |
| SCHEMBL3158764 | 0.81 | EPHX2 (0.73) | MAPK14LSSEPHX2NR1H4PPARG | |
| SCHEMBL31060682 | 0.81 | MAPK14 (1.00) | MAPK14LSSEPHX2NR1H4MEN1 | |
| SCHEMBL4316832 | 0.81 | KIF11 (0.89) | KIF11EPHX2MEN1KMT2AMAOB | |
| SCHEMBL4497840 | 0.80 | LSS (0.69) | MAPK14LSSEPHX2NR1H4PPARG | |
| SCHEMBL20477562 | 0.80 | L3MBTL1 (0.69) | MAPK14LSSEPHX2MEN1KMT2A | |
| SCHEMBL6572354 | 0.80 | HDAC6 (0.72) | MAPK14LSSEPHX2PPARGPPARA | |
| SCHEMBL3455877 | 0.80 | LSS (0.69) | MAPK14LSSEPHX2NR1H4PPARG | |
| SCHEMBL28909073 | 0.79 | KIF11 (0.86) | KIF11EPHX2MEN1KMT2AMAOB | |
| SCHEMBL507529 | 0.79 | LSS (0.68) | MAPK14LSSEPHX2NR1H4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458374-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051841-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | disclosed |