Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.54 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.54 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4849217 | 0.82 | UBE2T (0.50) | UBE2TASIC3LOXL2MAPTL3MBTL1 | |
| SCHEMBL14478202 | 0.81 | UBE2T (0.61) | UBE2TASIC3LOXL2MAPTL3MBTL1 | |
| SCHEMBL14478204 | 0.81 | UBE2T (0.61) | UBE2TASIC3LOXL2MAPTL3MBTL1 | |
| SCHEMBL19214783 | 0.79 | RAB9A (0.43) | MAPTRAB9ANPC1SMN1; SMN2MAPK1 | |
| SCHEMBL20661476 | 0.77 | CASP3 (0.45) | RAB9ANPC1SMN1; SMN2MAPK1GAA | |
| SCHEMBL2662248 | 0.77 | UBE2T (0.59) | UBE2TASIC3LOXL2MAPTL3MBTL1 | |
| SCHEMBL16411256 | 0.77 | L3MBTL1 (0.49) | UBE2TASIC3LOXL2MAPTL3MBTL1 | |
| SCHEMBL23222252 | 0.76 | UBE2T (0.50) | UBE2TASIC3LOXL2MAPTL3MBTL1 | |
| SCHEMBL9217943 | 0.76 | UBE2T (0.58) | UBE2TASIC3LOXL2MAPTL3MBTL1 | |
| SCHEMBL12511 | 0.75 | UBE2T (0.61) | UBE2TASIC3MAPTL3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397340-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002098850-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | disclosed |