Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16923005 | 0.93 | DRD4 (0.46) | CA2CA1CA9CA12SIGMAR1 | |
| SCHEMBL26698411 | 0.87 | SHBG (0.56) | TSHRCYP1A2CYP3A4NPC1RAB9A | |
| SCHEMBL21023624 | 0.84 | DRD4 (0.44) | CA2TSHRHTTKDM4ECYP3A4 | |
| SCHEMBL24146971 | 0.81 | DRD4 (0.42) | TSHRHTTKDM4ENPC1RAB9A | |
| SCHEMBL1261811 | 0.80 | CA2 (0.55) | CA2CA1CA9CA12SIGMAR1 | |
| SCHEMBL16922872 | 0.80 | ALDH1A1 (0.41) | TSHRCYP1A2CYP3A4MAPK1ALDH1A1 | |
| SCHEMBL318036 | 0.79 | CA2 (0.68) | CA2SIGMAR1ATMKDM4ECYP1A2 | |
| SCHEMBL731016 | 0.79 | TSHR (0.48) | TSHRCYP1A2CYP3A4MAPK1ALDH1A1 | |
| SCHEMBL29475007 | 0.79 | CA2 (0.68) | CA2SIGMAR1ATMKDM4ECYP1A2 | |
| SCHEMBL24161726 | 0.79 | CYP3A4 (0.42) | TSHRHTTKDM4ECYP3A4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108017665-A | A kind of preparation of L- α-choline glycerophosphatide and purification process | 湖南托阳制药有限公司 | 2018-05-11 | — | — | CN | claimed |
| CN-1247590-C | Process for synthesis of derivatives of 2,30dihydro-1,4-dioxino-[2,3-f]quinoline | WYETH CORP (US) | 2006-03-29 | — | — | CN | claimed |
| US-20040186123-A1 | Process for the synthesis of derivatives of 2, 3-dihydro-1, 4-dioxino- [2, 3-f] quinoline | WYETH | 2004-09-23 | — | — | US | claimed |
| CN-1509290-A | Process for synthesis of derivatives of 2,30dihydro-1,4-dioxino-[2,3-f]quinoline | — | 2004-06-30 | — | — | CN | claimed |
| US-6693197-B2 | Process for the synthesis of derivatives of 2,3-dihydro-1,4-dioxino- [2,3-f] quinoline | WYETH | 2004-02-17 | — | — | US | claimed |
| EP-1387845-A2 | PROCESSES FOR THE SYNTHESIS OF DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO-(2,3-f) QUINOLINE | Wyeth (US) | 2004-02-11 | — | — | EP | claimed |
| US-20020187983-A1 | Process for the synthesis of derivatives of 2, 3-dihydro-1, 4-dioxino- [2, 3-f] quinoline | WYETH | 2002-12-12 | — | — | US | claimed |
| WO-2002092602-A2 | PROCESSES FOR THE SYNTHESIS OF DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO-[2,3-f] QUINOLINE | WYETH (US) | 2002-11-21 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020187983-A1 | Process for the synthesis of derivatives of 2, 3-dihydro-1, 4-dioxino- [2, 3-f] quinoline | CYP1A1, CYP2F1, CYP1B1 | CA2 2223/4885CA1 1999/4885CA9 2627/4885 |
| US-20040186123-A1 | Process for the synthesis of derivatives of 2, 3-dihydro-1, 4-dioxino- [2, 3-f] quinoline | CYP1A1, CYP2F1, CYP1B1 | CA2 2223/4885CA1 1999/4885CA9 2627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.