Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | FABP1 | P07148 | 1/20 | 0.42 |
| ▸ | FABP6 | P51161 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.41 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4064447 | 0.98 | SMN1; SMN2 (0.47) | SMN1; SMN2HSD17B10ALDH1A1RAB9ATP53 | |
| SCHEMBL5603848 | 0.90 | ALDH1A1 (0.43) | SMN1; SMN2HSD17B10ALDH1A1RAB9ATP53 | |
| Hydrochloric Acid SCHEMBL6791179 | 0.81 | L3MBTL1 (0.50) | SMN1; SMN2ALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL9204216 | 0.80 | ELANE (0.43) | PIM1HTT | |
| SCHEMBL18541915 | 0.76 | HTT (0.52) | SMN1; SMN2RAB9ATP53MEN1KMT2A | |
| SCHEMBL8824655 | 0.75 | MAPT (0.52) | ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL2528923 | 0.71 | ALDH1A1 (0.54) | HSD17B10ALDH1A1MEN1KMT2AGAA | |
| SCHEMBL12114155 | 0.71 | APP (0.45) | LMNAPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL2836274 | 0.71 | MEN1 (0.46) | SMN1; SMN2HSD17B10ALDH1A1RAB9ATP53 | |
| SCHEMBL14868919 | 0.70 | MEN1 (0.55) | SMN1; SMN2HSD17B10ALDH1A1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365809-B1 | PYRAZINOPYRAZINES AND DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMA INC (US) | 2018-07-18 | — | — | EP | disclosed |
| EP-1490343-A1 | NEW ARYL IMIDAZOLES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS | Neurogen Corporation (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003082829-A1 | NEW ARYL IMIDAZOLES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2003-10-09 | — | — | WO | disclosed |
| EP-0829480-B1 | Tetrazolyl-substituted quinuclidines as substance P antagonists | PFIZER (US) | 2000-12-20 | — | — | EP | disclosed |
| US-5939434-A | Tetrazolyl-substituted quinuclidines as substance P antagonists | PFIZER PHARMACEUTICALS INC. (JP) | 1999-08-17 | — | — | US | disclosed |
| EP-0829480-A2 | Tetrazolyl-substituted quinuclidines as substance P antagonists | PFIZER INC. (US) | 1998-03-18 | — | — | EP | disclosed |