Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6572637 | 0.81 | HPGDS (0.41) | PIK3CAPIK3CDPIK3CBPI4KAPIK3CG | |
| SCHEMBL4898151 | 0.81 | KDM4E (0.51) | MAPTKDM4E | |
| SCHEMBL4412336 | 0.74 | SMN1; SMN2 (0.42) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL29875184 | 0.74 | ATR (0.45) | MKNK1MKNK2CHEK1FYNHSD17B1 | |
| SCHEMBL19926325 | 0.74 | ATR (0.45) | MKNK1MKNK2CHEK1FYNHSD17B1 | |
| SCHEMBL1012506 | 0.72 | AKT2 (0.47) | MKNK1MKNK2CHEK1L3MBTL1CYP1A2 | |
| SCHEMBL1854897 | 0.71 | ADORA2B (0.44) | MKNK1MKNK2CYP2A6PIK3CAPIK3CD | |
| SCHEMBL4009647 | 0.71 | MAPK1 (0.47) | LOXL2MAPTKDM4E | |
| SCHEMBL19459337 | 0.71 | KIF11 (0.42) | MKNK1MKNK2L3MBTL1KDM4E | |
| Hydrochloric Acid SCHEMBL1858316 | 0.70 | ADORA2B (0.43) | MKNK1MKNK2CYP2A6PIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480973-A1 | 1,4-DISUBSTITUTED BENZOFUSED CYCLOALKYL UREA COMPOUNDS USEFUL IN TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003072569-A1 | 1,4-DISUBSTITUTED BENZOFUSED CYCLOALKYL UREA COMPOUNDS USEFUL IN TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-09-04 | — | — | WO | disclosed |