Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 2/20 | 0.37 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | HEXA | P06865 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20837302 | 0.85 | ENPP1 (0.41) | SMN1; SMN2NPC1GAAIKBKBMAP3K14 | |
| SCHEMBL1012506 | 0.84 | AKT2 (0.47) | SMN1; SMN2NPC1GAAKMT2AMEN1 | |
| SCHEMBL4898151 | 0.83 | KDM4E (0.51) | SMN1; SMN2NPC1GAAKMT2AMEN1 | |
| SCHEMBL19459337 | 0.82 | KIF11 (0.42) | NPC1IKBKBKMT2AMEN1ALDH1A1 | |
| SCHEMBL6572637 | 0.81 | HPGDS (0.41) | NPC1GAAIKBKBMAP3K14CHUK | |
| SCHEMBL8490498 | 0.79 | CCNE2 (0.44) | SMN1; SMN2NPC1GAAKMT2AMEN1 | |
| SCHEMBL842957 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1GAAIKBKBMAP3K14 | |
| SCHEMBL7472539 | 0.76 | USP7 (0.36) | KMT2AMEN1ALDH1A1MITFTP53 | |
| SCHEMBL4009647 | 0.76 | MAPK1 (0.47) | KMT2AALDH1A1MAPK1LMNA | |
| SCHEMBL6632491 | 0.74 | MKNK1 (0.40) | PIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670787-A4 | CYTOKINE INHIBITORS | KEMIA INC (US) | 2009-04-22 | — | — | EP | disclosed |
| US-20070010548-A1 | Compounds having inhibitive activity of phosphatidylinositol 3-kinase and methods of use thereof | ZENTARIS GMBH (DE) | 2007-01-11 | — | — | US | disclosed |
| EP-1670787-A2 | CYTOKINE INHIBITORS | Kemia, INC. (US) | 2006-06-21 | — | — | EP | disclosed |
| EP-1648463-A2 | COMPOUNDS HAVING INHIBITIVE ACTIVITY OF PHOSPHATIDYLINOSITOL 3-KINASE AND METHODS OF USE THEREOF | Zentaris GmbH (DE) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005023761-A2 | CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2005-03-17 | — | — | WO | disclosed |
| WO-2005016245-A2 | COMPOUNDS HAVING INHIBITIVE ACTIVITY OF PHOSPHATIDYLINOSITOL 3-KINASE AND METHODS OF USE THEREOF | ZENTARIS GMBH (DE) | 2005-02-24 | — | — | WO | disclosed |
| EP-1480973-A1 | 1,4-DISUBSTITUTED BENZOFUSED CYCLOALKYL UREA COMPOUNDS USEFUL IN TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003072569-A1 | 1,4-DISUBSTITUTED BENZOFUSED CYCLOALKYL UREA COMPOUNDS USEFUL IN TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010548-A1 | Compounds having inhibitive activity of phosphatidylinositol 3-kinase and methods of use thereof | IPMK, PI4KB, PDPK1 | SMN1; SMN2 4567/4885NPC1 3590/4885GAA 1644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.