Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10187028 | 0.84 | SMN1; SMN2 (0.52) | RAB9AMAPTNPC1SMN1; SMN2MEN1 | |
| SCHEMBL6195935 | 0.84 | RAB9A (0.49) | RAB9AMAPTKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL2187619 | 0.83 | RAB9A (0.48) | RAB9AMAPTKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL6681499 | 0.82 | RAB9A (0.47) | RAB9AMAPTKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL10187027 | 0.80 | SMN1; SMN2 (0.51) | RAB9AMAPTKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL21909759 | 0.78 | RAB9A (0.52) | RAB9AMAPTKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL6198600 | 0.77 | NPC1 (0.64) | RAB9AMAPTNPC1SMN1; SMN2MEN1 | |
| SCHEMBL21376322 | 0.73 | RAB9A (0.46) | RAB9AMAPTKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL3206132 | 0.72 | GSR (0.53) | RAB9AKDM4ENPC1CDK2KMT2A | |
| SCHEMBL6644918 | 0.71 | CDK2 (0.54) | MAPTSMN1; SMN2CDK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444207-A2 | SUBSTITUTED PYRAZOLYL-COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003024935-A2 | SUBSTITUTED PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2003-03-27 | — | — | WO | disclosed |