Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.64 |
| ▸ | RAB9A | P51151 | 6/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | TP53 | P04637 | 3/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | STAT3 | P40763 | 1/20 | 0.64 |
| ▸ | STAT1 | P42224 | 1/20 | 0.64 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.64 |
| ▸ | RELA | Q04206 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6195935 | 0.87 | RAB9A (0.49) | NPC1RAB9AMAPTSMN1; SMN2TP53 | |
| SCHEMBL2187619 | 0.82 | RAB9A (0.48) | NPC1RAB9AMAPTSMN1; SMN2TP53 | |
| SCHEMBL6681499 | 0.78 | RAB9A (0.47) | NPC1RAB9AMAPTSMN1; SMN2TP53 | |
| SCHEMBL6632697 | 0.77 | RAB9A (0.48) | NPC1RAB9AMAPTSMN1; SMN2TP53 | |
| SCHEMBL3206132 | 0.75 | GSR (0.53) | NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL1160454 | 0.74 | NPC1 (0.49) | NPC1RAB9AMAPTSMN1; SMN2TP53 | |
| SCHEMBL10187028 | 0.74 | SMN1; SMN2 (0.52) | NPC1RAB9AMAPTSMN1; SMN2TP53 | |
| SCHEMBL6617104 | 0.73 | PKM (0.47) | NPC1RAB9AMAPTKMT2A | |
| SCHEMBL21909759 | 0.73 | RAB9A (0.52) | NPC1RAB9AMAPTSMN1; SMN2TP53 | |
| SCHEMBL21376322 | 0.72 | RAB9A (0.46) | NPC1RAB9AMAPTSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501805-A1 | SUBSTITUTED PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003095430-A1 | SUBSTITUTED PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2003-11-20 | — | — | WO | disclosed |