Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 5/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21909759 | 0.86 | RAB9A (0.52) | RAB9ANPC1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL6195935 | 0.85 | RAB9A (0.49) | RAB9ANPC1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL2187619 | 0.84 | RAB9A (0.48) | RAB9ANPC1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL6632697 | 0.82 | RAB9A (0.48) | RAB9ANPC1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL10187028 | 0.79 | SMN1; SMN2 (0.52) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL6198600 | 0.78 | NPC1 (0.64) | RAB9ANPC1SMN1; SMN2MAPTMAP4K1 | |
| SCHEMBL10187027 | 0.75 | SMN1; SMN2 (0.51) | RAB9ANPC1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL6645881 | 0.74 | ROCK2 (0.43) | RAB9ANPC1MAPTKDM4E | |
| SCHEMBL21376322 | 0.74 | RAB9A (0.46) | RAB9ANPC1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL3206132 | 0.73 | GSR (0.53) | RAB9ANPC1KDM4ECDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444207-A2 | SUBSTITUTED PYRAZOLYL-COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003024935-A2 | SUBSTITUTED PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2003-03-27 | — | — | WO | disclosed |