Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | PNMT | P11086 | 7/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615906 | 0.99 | MEN1 (0.60) | MEN1KMT2APNMTADRA2AADRA2B | |
| SCHEMBL6613682 | 0.79 | MEN1 (0.68) | MEN1KMT2APNMTGRIN2B | |
| SCHEMBL6615903 | 0.78 | PNMT (0.43) | PNMTADRA2AADRA2BADRA2CGRIN2B | |
| SCHEMBL6616489 | 0.78 | MEN1 (0.97) | MEN1KMT2APNMT | |
| SCHEMBL6618257 | 0.76 | MEN1 (0.68) | MEN1KMT2A | |
| SCHEMBL7679653 | 0.74 | MAPT (0.42) | MEN1KMT2AGRIN2BALDH1A1CYP1A2 | |
| SCHEMBL23802723 | 0.73 | LOXL2 (0.48) | KMT2AALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL19975549 | 0.73 | LOXL2 (0.48) | KMT2AALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL27768825 | 0.72 | KDM1A (0.48) | MEN1KMT2AALDH1A1 | |
| SCHEMBL13186543 | 0.71 | LOXL2 (0.50) | KMT2AALDH1A1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1481975-A1 | Inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-01 | — | — | EP | disclosed |
| US-6455523-B1 | ADMINISTERING 1,4-BENZODIAZEPINE DERIVATIVE AS ANTITUMOR OR ANTICARCINOGENIC AGENT | BRISTOL-MYERS SQUIBB COMPANY | 2002-09-24 | — | — | US | disclosed |
| US-6011029-A | BENZODIAZEPINE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-01-04 | — | — | US | disclosed |