Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NPY1R | P25929 | 1/20 | 0.52 |
| ▸ | NPY2R | P49146 | 1/20 | 0.52 |
| ▸ | CTSV | O60911 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | BCL9 | O00512 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5327852 | 0.81 | ALDH1A1 (0.68) | KMT2AALDH1A1MEN1PKMPOLB | |
| SCHEMBL28362604 | 0.81 | POLB (0.59) | KMT2AALDH1A1MEN1PKMPOLB | |
| SCHEMBL6634172 | 0.78 | MAPT (0.56) | KMT2AALDH1A1MEN1PKMPOLB | |
| SCHEMBL6316599 | 0.78 | CTSV (0.53) | KMT2AALDH1A1MEN1PKMPOLB | |
| SCHEMBL27136306 | 0.77 | ALDH1A1 (0.54) | KMT2AALDH1A1MEN1PKMPOLB | |
| SCHEMBL28524078 | 0.77 | MEN1 (0.58) | KMT2AALDH1A1MEN1PKMPOLB | |
| SCHEMBL28048707 | 0.76 | KMT2A (0.59) | KMT2AALDH1A1PKMCTSVCTSL | |
| SCHEMBL6184844 | 0.76 | ALDH1A1 (0.53) | KMT2AALDH1A1MEN1PKMPOLB | |
| SCHEMBL8589692 | 0.76 | ALDH1A1 (0.53) | KMT2AALDH1A1MEN1PKMPOLB | |
| SCHEMBL10915060 | 0.75 | ALDH1A1 (0.63) | KMT2AALDH1A1MEN1PKMPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483268-A2 | INDOLYL-UREA DERIVATIVES OF THIENOPYRIDINES USEFUL AS ANTI-ANGIOGENIC AGENTS | PFIZER INC. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003074529-A2 | iNDOLYL-UREA DERIVATIVES OF THIENOPYRIDINES USEFUL AS ANTI-ANGIOGENIC AGENTS | PFIZER INC. (US) | 2003-09-12 | — | — | WO | disclosed |