Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | LIPE | Q05469 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11851679 | 0.98 | ELANE (0.46) | ELANELIPEHPGDCYP11B1CYP11B2 | |
| SCHEMBL56865 | 0.80 | KMT2A (0.50) | ELANELIPEHPGDCYP11B1CYP11B2 | |
| SCHEMBL7063178 | 0.80 | ELANE (0.50) | ELANELIPEHPGDCYP11B1CYP11B2 | |
| SCHEMBL292790 | 0.78 | ELANE (0.53) | ELANELIPEHPGDCYP11B1CYP11B2 | |
| SCHEMBL1254449 | 0.78 | ELANE (0.48) | ELANELIPEHPGDCYP11B1CYP11B2 | |
| SCHEMBL59462 | 0.78 | ELANE (0.48) | ELANELIPEHPGDCYP11B1CYP11B2 | |
| SCHEMBL81261 | 0.76 | MEN1 (0.52) | ELANELIPEHPGDCYP11B1CYP11B2 | |
| SCHEMBL9860326 | 0.76 | CYP11B1 (0.49) | ELANELIPEHPGDCYP11B1CYP11B2 | |
| SCHEMBL76135 | 0.76 | LMNA (0.64) | ELANEHPGDCYP11B1CYP11B2MEN1 | |
| SCHEMBL54704 | 0.76 | ELANE (0.47) | ELANELIPEHPGDCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472219-A1 | NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003053978-A1 | NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2003-07-03 | — | — | WO | disclosed |